tsRNADisease

Entry Detail

General Information

Database ID:	TRD03809
Confidence:	Median
Contents:	>> tsRNA Information >> tsRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference

tsRNA Information

tsRNA Name:

ProAGG-31

tsRNA Type:

tRF-5

Amino acid and Anticodon:

ProAGG

Sequence:

N/A

Related Target:

Predicted Target:

External Links:

MINTbase ID:	N/A
tRFdb ID:	N/A

tsRNA Association Statistics

Total Associated Disease Number:	3 More Information
Network: (Display the first 15 nodes)

Disease Information

	MeSH	Disease Ontology
Disease ID:	D007248	DOID:12336
Disease Name:	Infertility, Male	male infertility
Category:	MeSH	Disease Ontology
Type:	Urogenital Diseases	disease of anatomical entity
Define:	The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.	N/A
Alias:	Sterility, Male//Sub-Fertility, Male//Subfertility, Male	N/A

Disease Association Statistics

Total Associated tsRNA Number:	26 More Information
Network: (Display the first 15 nodes)

Evidence Support

Strong Evidence:	N/A
Weak Evidence:	Sequencing

Reference

[1] PubMed ID:	30992999
Disease Name:	Infertility, Male
Tissue:	human sperm samples
Dysfunction Pattern:	Up-Regulation
Validated Method:	Sequencing
Description:	Among these tsRNAs, five tsRNAs, including GlyGCC-30-1 (the first number indicates the length of the tsRNA, the second number indicates the isoform of tsRNAs with the same length), GlyGCC-30-2, ThrTGT-38, ThrTGT-39, and GluTTC-23, were downregulated in the L-GQE group. Five other tsRNAs, including ProAGG-32, ProTGG-32, ProAGG-31, AsnATT-20, and ArgCCG-33, were upregulated (Fig. 1d, e).
Comparision:	L-GQE VS H-GQE
Mechanism:	Thus, the mis-regulation of these tsRNAs in sperm might contribute to poor sperm quality and abnormal early embryo development, a notion which warrants future investigation.