Entry Detail


General Information

Database ID:TRD03796
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-1.16-chrM.Phe-GAA
tsRNA Type:tRF-5
Amino acid and Anticodon:PheGAA
Sequence:GTTTATGTAGCTTACC
Related Target:N/A
Predicted Target:PCNT//ADAMTS6//CYB5D1//KIF1B//GOLGA6L4//ADAMTSL1//CGGBP1//STAG1//STAG2//USP47
External Links:
MINTbase ID:tRF-16-7X9PN5D
tRFdb ID:N/A

[1] gtRNAdb_ID:-
Anticodon:PheGAA
tRNA_number:trnaMT
Chromosome:MT
Strand:+
Coordinate:Start Site(bp): 577        End Site(bp): 592



tsRNA Association Statistics

Total Associated Disease Number:3
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D015179DOID:9256
Disease Name:Colorectal Neoplasmscolorectal cancer
Category:MeSHDisease Ontology
Type:Neoplasms//Digestive System Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.A large intestine cancer that is located_in the colon and/or located_in the rectum.
Alias:Colorectal Cancer//Colorectal Carcinoma//Colorectal Tumors//Neoplasms, ColorectalN/A



Disease Association Statistics

Total Associated tsRNA Number:195
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR//Western blot
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:37864471
Disease Name:Colorectal Neoplasms
Tissue:Colon
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR//Western blot//High-throughput sequencing
Description:Our findings demonstrated that tRF‐16‐7X9PN5D expression was substantially downregulated in radioresistant CRC cells.
Comparision:Radiation‐Resistant VS Wild‐Type Cells
Mechanism:Furthermore, tRF‐16‐7X9PN5D could promote CRC cells' ability to proliferate, migrate, invade and obtain radiation resistance by targeting MKNK1. Finally, tRF‐16‐7X9PN5D could regulate eIF4E phosphorylation via MKNK1. This investigation indicated that tRF‐16‐7X9PN5D has an essential regulatory role in the radiation resistance of CRC by directly targeting MKNK1, and may be a new pathway for regulating the CRC radiosensitivity.