Entry Detail


General Information

Database ID:TRD03703
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRFLys-CTT-010
tsRNA Type:tRF-5
Amino acid and Anticodon:LysCTT
Sequence:GCCCGGCTAGCTCAGTCGGTAGAGCATGGGA
Related Target:G6PC
Predicted Target:EBI3//ZDHHC3//GPER1//RPS6KA2//SMOC2//TNRC18//EXOC3//LRRTM1//SLC6A9//RDX
External Links:
MINTbase ID:tRF-31-PSQP4PW3FJIKB
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Lys-CTT-4-1
Anticodon:LysCTT
tRNA_number:trna10
Chromosome:16
Strand:+
Coordinate:Start Site(bp): 3241501        End Site(bp): 3241531

[2] gtRNAdb_ID:tRNA-Lys-CTT-1-1
Anticodon:LysCTT
tRNA_number:trna13
Chromosome:14
Strand:-
Coordinate:Start Site(bp): 58706655        End Site(bp): 58706685

[3] gtRNAdb_ID:tRNA-Lys-CTT-1-2
Anticodon:LysCTT
tRNA_number:trna2
Chromosome:15
Strand:+
Coordinate:Start Site(bp): 79152904        End Site(bp): 79152934



tsRNA Association Statistics

Total Associated Disease Number:1
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D001943DOID:1612
Disease Name:Breast Neoplasmsbreast cancer
Category:MeSHDisease Ontology
Type:Neoplasms//Skin and Connective Tissue Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:Tumors or cancer of the human BREAST.A thoracic cancer that originates in the mammary gland.
Alias:Breast Cancer//Breast Carcinoma//Breast Tumors//Cancer of Breast//Cancer of the Breast//Human Mammary Carcinoma//Malignant Neoplasm of Breast//Malignant Tumor of Breast//Mammary Cancer//Mammary Carcinoma, Human//Mammary Neoplasm, Human//Mammary Neoplasms, Human//Neoplasms, Breast//Tumors, Breastbreast tumor//malignant neoplasm of breast//malignant tumor of the breast//mammary cancer//mammary neoplasm//mammary tumor//primary breast cancer



Disease Association Statistics

Total Associated tsRNA Number:549
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:34216208
Disease Name:Breast Neoplasms
Tissue:Breast Cancer
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:tRNA-derived fragment tRFLys-CTT-010 promotes triple-negative breast cancer progression by regulating glucose metabolism via G6PC.
Comparision:Cancer VS Normal
Mechanism:tRFLys-CTT-010 is increased in TNBC and associates with tumor proliferation and metastasis. tRFLys-CTT-010 promotes TNBC progression by regulating glucose metabolism via G6PC, a key enzyme in glucose homeostasis. Thus, tRFLys-CTT-010/G6PC axis can be a potential therapeutic target for TNBC treatment.