Entry Detail


General Information

Database ID:TRD03580
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-Leu-CAA-003
tsRNA Type:tRF-5
Amino acid and Anticodon:LeuCAA
Sequence:GTCAGGATGGCCGAGC
Related Target:AKT1; MYD88
Predicted Target:GSTT2B//GSTT2//TENM4//PSAPL1//SEC13//C6orf201//NOP9//GPSM1//RNF225//TREX1
External Links:
MINTbase ID:tRF-16-SP5830D
tRFdb ID:tRFdb-5023a

[1] gtRNAdb_ID:tRNA-Leu-CAA-6-1
Anticodon:LeuCAA
tRNA_number:trna66
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161581804        End Site(bp): 161581819

[2] gtRNAdb_ID:tRNA-Leu-CAG-2-1
Anticodon:LeuCAG
tRNA_number:trna17
Chromosome:16
Strand:+
Coordinate:Start Site(bp): 57333863        End Site(bp): 57333878

[3] gtRNAdb_ID:tRNA-Leu-CAG-2-2
Anticodon:LeuCAG
tRNA_number:trna26
Chromosome:16
Strand:-
Coordinate:Start Site(bp): 57334459        End Site(bp): 57334474

[4] gtRNAdb_ID:tRNA-Leu-CAG-1-1
Anticodon:LeuCAG
tRNA_number:trna34
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161411323        End Site(bp): 161411338

[5] gtRNAdb_ID:tRNA-Leu-CAG-1-2
Anticodon:LeuCAG
tRNA_number:trna36
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161418741        End Site(bp): 161418756

[6] gtRNAdb_ID:tRNA-Leu-CAG-1-3
Anticodon:LeuCAG
tRNA_number:trna38
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161426122        End Site(bp): 161426137

[7] gtRNAdb_ID:tRNA-Leu-CAG-1-4
Anticodon:LeuCAG
tRNA_number:trna40
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161433532        End Site(bp): 161433547

[8] gtRNAdb_ID:tRNA-Leu-CAG-1-5
Anticodon:LeuCAG
tRNA_number:trna42
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161440913        End Site(bp): 161440928

[9] gtRNAdb_ID:tRNA-Leu-CAG-1-6
Anticodon:LeuCAG
tRNA_number:trna67
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161500199        End Site(bp): 161500214

[10] gtRNAdb_ID:tRNA-Leu-CAG-1-7
Anticodon:LeuCAG
tRNA_number:trna7
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 26521436        End Site(bp): 26521451



tsRNA Association Statistics

Total Associated Disease Number:6
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D001943DOID:1612
Disease Name:Breast Neoplasmsbreast cancer
Category:MeSHDisease Ontology
Type:Neoplasms//Skin and Connective Tissue Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:Tumors or cancer of the human BREAST.A thoracic cancer that originates in the mammary gland.
Alias:Breast Cancer//Breast Carcinoma//Breast Tumors//Cancer of Breast//Cancer of the Breast//Human Mammary Carcinoma//Malignant Neoplasm of Breast//Malignant Tumor of Breast//Mammary Cancer//Mammary Carcinoma, Human//Mammary Neoplasm, Human//Mammary Neoplasms, Human//Neoplasms, Breast//Tumors, Breastbreast tumor//malignant neoplasm of breast//malignant tumor of the breast//mammary cancer//mammary neoplasm//mammary tumor//primary breast cancer



Disease Association Statistics

Total Associated tsRNA Number:549
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:32814252
Disease Name:Breast Neoplasms
Tissue:Plasma
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:Thirty tRFs and tiRNAs were selected by high-throughput sequencing in screening phase and then assessed in training, testing, and external validation phases byqRT-PCR. Six tRFs (tRF-Glu-CTC-003, tRF-Gly-CCC-007, tRF-Gly-CCC-008, tRF-Leu-CAA-003, tRF-Ser-TGA-001, and tRF-Ser-TGA-002) were found significantly downregulated in plasma samples of patients with EBC compared with normal controls.
Comparision:Cancer VS Normal
Mechanism:It was primarily intracellular and involved in biosynthetic and catabolic processes.