Entry Detail


General Information

Database ID:TRD03520
Confidence:Median
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-His-GTG-008
tsRNA Type:tRF-5
Amino acid and Anticodon:HisGTG
Sequence:GCCGTGATCGTATAGTGGTTAGTACTCTGCG
Related Target:N/A
Predicted Target:SHF//ARHGAP25//EVPLL//SUSD5//OTUB2//RBMXL2//LHFPL6//FOXC1//PTPRN//ELK4
External Links:
MINTbase ID:tRF-31-PW5SVP9N15WV0
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-His-GTG-1-4
Anticodon:HisGTG
tRNA_number:trna111
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 147774886        End Site(bp): 147774916

[2] gtRNAdb_ID:tRNA-His-GTG-1-1
Anticodon:HisGTG
tRNA_number:trna118
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 145396922        End Site(bp): 145396952

[3] gtRNAdb_ID:tRNA-His-GTG-1-2
Anticodon:HisGTG
tRNA_number:trna16
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 146544773        End Site(bp): 146544803

[4] gtRNAdb_ID:tRNA-His-GTG-1-3
Anticodon:HisGTG
tRNA_number:trna21
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 147753471        End Site(bp): 147753501

[5] gtRNAdb_ID:tRNA-His-GTG-1-9
Anticodon:HisGTG
tRNA_number:trna1
Chromosome:15
Strand:+
Coordinate:Start Site(bp): 45493349        End Site(bp): 45493379

[6] gtRNAdb_ID:tRNA-His-GTG-1-8
Anticodon:HisGTG
tRNA_number:trna8
Chromosome:15
Strand:-
Coordinate:Start Site(bp): 45492652        End Site(bp): 45492682

[7] gtRNAdb_ID:tRNA-His-GTG-1-7
Anticodon:HisGTG
tRNA_number:trna9
Chromosome:15
Strand:-
Coordinate:Start Site(bp): 45490845        End Site(bp): 45490875

[8] gtRNAdb_ID:tRNA-His-GTG-1-5
Anticodon:HisGTG
tRNA_number:trna33
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 27125906        End Site(bp): 27125936

[9] gtRNAdb_ID:tRNA-His-GTG-1-6
Anticodon:HisGTG
tRNA_number:trna7
Chromosome:9
Strand:-
Coordinate:Start Site(bp): 14433979        End Site(bp): 14434009



tsRNA Association Statistics

Total Associated Disease Number:4
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D009914DOID:5773
Disease Name:Oral Submucous Fibrosisoral submucous fibrosis
Category:MeSHDisease Ontology
Type:Stomatognathic Diseasesdisease of anatomical entity
Define:Irreversible FIBROSIS of the submucosal tissue of the MOUTH.A mouth disease that is characterized by juxta-epithelial inflammatory reaction and progressive fibrosis of the submucosal tissues.
Alias:N/AOral cavity Submucous Fibrosis//Oral submucosal fibrosis//Oral submucosal fibrosis, including of tongue



Disease Association Statistics

Total Associated tsRNA Number:126
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:N/A
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:34558114
Disease Name:Oral Submucous Fibrosis
Tissue:Oral Submucous Fibrosis
Dysfunction Pattern:Up-Regulation
Validated Method:High-throughput sequencing
Description:Of 126 tsRNAs in OSF were dysregulated, including 73 upregulated tsRNAs and 53 downregulated tsRNAs. The downregulated tiRNA-Val-CAC-002,tRF-Asn-GTT-005, tRF-Trp-CCA-007 and upregulated tRF-Gly-TCC-016,tRF-Pro-TGG-009 showed significant differences by qRT-PCR validation.
Comparision:Disease VS Control
Mechanism:tRNA-derived fragments are dysregulated and could be involved in the pathogenesis of oral submucous fibrosis.