Entry Detail


General Information

Database ID:TRD03519
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-His-GTG-008
tsRNA Type:tRF-5
Amino acid and Anticodon:HisGTG
Sequence:GCCGTGATCGTATAGTGGTTAGTACTCTGCG
Related Target:N/A
Predicted Target:SHF//ARHGAP25//EVPLL//SUSD5//OTUB2//RBMXL2//LHFPL6//FOXC1//PTPRN//ELK4
External Links:
MINTbase ID:tRF-31-PW5SVP9N15WV0
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-His-GTG-1-4
Anticodon:HisGTG
tRNA_number:trna111
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 147774886        End Site(bp): 147774916

[2] gtRNAdb_ID:tRNA-His-GTG-1-1
Anticodon:HisGTG
tRNA_number:trna118
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 145396922        End Site(bp): 145396952

[3] gtRNAdb_ID:tRNA-His-GTG-1-2
Anticodon:HisGTG
tRNA_number:trna16
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 146544773        End Site(bp): 146544803

[4] gtRNAdb_ID:tRNA-His-GTG-1-3
Anticodon:HisGTG
tRNA_number:trna21
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 147753471        End Site(bp): 147753501

[5] gtRNAdb_ID:tRNA-His-GTG-1-9
Anticodon:HisGTG
tRNA_number:trna1
Chromosome:15
Strand:+
Coordinate:Start Site(bp): 45493349        End Site(bp): 45493379

[6] gtRNAdb_ID:tRNA-His-GTG-1-8
Anticodon:HisGTG
tRNA_number:trna8
Chromosome:15
Strand:-
Coordinate:Start Site(bp): 45492652        End Site(bp): 45492682

[7] gtRNAdb_ID:tRNA-His-GTG-1-7
Anticodon:HisGTG
tRNA_number:trna9
Chromosome:15
Strand:-
Coordinate:Start Site(bp): 45490845        End Site(bp): 45490875

[8] gtRNAdb_ID:tRNA-His-GTG-1-5
Anticodon:HisGTG
tRNA_number:trna33
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 27125906        End Site(bp): 27125936

[9] gtRNAdb_ID:tRNA-His-GTG-1-6
Anticodon:HisGTG
tRNA_number:trna7
Chromosome:9
Strand:-
Coordinate:Start Site(bp): 14433979        End Site(bp): 14434009



tsRNA Association Statistics

Total Associated Disease Number:4
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D009765DOID:9970
Disease Name:Obesityobesity
Category:MeSHDisease Ontology
Type:Nutritional and Metabolic Diseases//Pathological Conditions, Signs and Symptomsdisease of metabolism
Define:A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.
Alias:N/AN/A



Disease Association Statistics

Total Associated tsRNA Number:55
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:37352601
Disease Name:Obesity
Tissue:Brown Adipocytes
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:Further, qRT-PCR validated that three notably upregulated tRFs (tRF-Gly-GCC-007, tRF-Gly-GCC-008, and tRF-Gly-GCC-012) were in accordance with the sequencing result.
Comparision:Forskolin VS Control
Mechanism:Target genes of tRFs were involved in positive regulation of protein phosphorylation and cell adhesion process by significantly downregulating UCHL6 expression, which might participate in lipolysis. This study might provide therapeutic targets and potential diagnostic biomarkers for obesity treatment.