Entry Detail


General Information

Database ID:TRD03461
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tsRNA-5008a
tsRNA Type:tRF-5
Amino acid and Anticodon:GlyTCC
Sequence:GCGTTGGTGGTATAGTGGTGAGC
Related Target:N/A
Predicted Target:PHGDH//SPSB1//SLC6A9//ICAM5//ENDOG//CPHXL//ZNF775//MRPL54//CAPSL//SLC34A1
External Links:
MINTbase ID:tRF-23-QNR8VP949
tRFdb ID:tRFdb-5008a

[1] gtRNAdb_ID:tRNA-Gly-TCC-4-1
Anticodon:GlyTCC
tRNA_number:trna82
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161410010        End Site(bp): 161410032

[2] gtRNAdb_ID:tRNA-Gly-TCC-2-1
Anticodon:GlyTCC
tRNA_number:trna117
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 145397913        End Site(bp): 145397935

[3] gtRNAdb_ID:tRNA-Gly-TCC-2-6
Anticodon:GlyTCC
tRNA_number:trna45
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161500903        End Site(bp): 161500925

[4] gtRNAdb_ID:tRNA-Gly-TCC-2-5
Anticodon:GlyTCC
tRNA_number:trna70
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161439596        End Site(bp): 161439618

[5] gtRNAdb_ID:tRNA-Gly-TCC-2-4
Anticodon:GlyTCC
tRNA_number:trna73
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161432215        End Site(bp): 161432237

[6] gtRNAdb_ID:tRNA-Gly-TCC-2-3
Anticodon:GlyTCC
tRNA_number:trna76
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161424805        End Site(bp): 161424827

[7] gtRNAdb_ID:tRNA-Gly-TCC-2-2
Anticodon:GlyTCC
tRNA_number:trna79
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161417424        End Site(bp): 161417446



tsRNA Association Statistics

Total Associated Disease Number:2
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D001281DOID:0060224
Disease Name:Atrial Fibrillationatrial fibrillation
Category:MeSHDisease Ontology
Type:Cardiovascular Diseases//Pathological Conditions, Signs and Symptomsdisease of anatomical entity
Define:Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.A heart conduction disease that is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular and has symptoms palpitations, weakness, fatigue, lightheadedness, dizziness, confusion, shortness of breath and chest pain.
Alias:Auricular Fibrillation//Familial Atrial Fibrillation//Paroxysmal Atrial Fibrillation//Persistent Atrial FibrillationA-fib//AFib



Disease Association Statistics

Total Associated tsRNA Number:38
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:38190870
Disease Name:Atrial Fibrillation
Tissue:atrial myocardial tissue of AF mice
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:RNA-Seq revealed tsRNA-5008a upregulated in the atrial myocardial tissue of AF mice.
Comparision:AF VS Normal
Mechanism:In conclusion, we have demonstrated that AF development accompanied by ferroptosis and blocking ferroptosis have an ameliorating effect on AF. A total of 9 tsRNAs differentially expressed in fibrotic AF atrial tissue, including tsRNA-5008a, and knockdown of tsRNA-5008a significantly suppressed ferroptosis through targeting SLC7A11 and diminished AF both in vitro and in vivo.