Entry Detail


General Information

Database ID:TRD03439
Confidence:Median
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-5008b
tsRNA Type:tRF-5
Amino acid and Anticodon:GlyTCC
Sequence:GCGTTGGTGGTATAGTGGTGAGC
Related Target:N/A
Predicted Target:PHGDH//SPSB1//SLC6A9//ICAM5//ENDOG//CPHXL//ZNF775//MRPL54//CAPSL//SLC34A1
External Links:
MINTbase ID:tRF-23-QNR8VP949
tRFdb ID:tRFdb-5008b

[1] gtRNAdb_ID:tRNA-Gly-TCC-4-1
Anticodon:GlyTCC
tRNA_number:trna82
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161410010        End Site(bp): 161410032

[2] gtRNAdb_ID:tRNA-Gly-TCC-2-1
Anticodon:GlyTCC
tRNA_number:trna117
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 145397913        End Site(bp): 145397935

[3] gtRNAdb_ID:tRNA-Gly-TCC-2-6
Anticodon:GlyTCC
tRNA_number:trna45
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161500903        End Site(bp): 161500925

[4] gtRNAdb_ID:tRNA-Gly-TCC-2-5
Anticodon:GlyTCC
tRNA_number:trna70
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161439596        End Site(bp): 161439618

[5] gtRNAdb_ID:tRNA-Gly-TCC-2-4
Anticodon:GlyTCC
tRNA_number:trna73
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161432215        End Site(bp): 161432237

[6] gtRNAdb_ID:tRNA-Gly-TCC-2-3
Anticodon:GlyTCC
tRNA_number:trna76
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161424805        End Site(bp): 161424827

[7] gtRNAdb_ID:tRNA-Gly-TCC-2-2
Anticodon:GlyTCC
tRNA_number:trna79
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161417424        End Site(bp): 161417446



tsRNA Association Statistics

Total Associated Disease Number:2
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D015179DOID:9256
Disease Name:Colorectal Neoplasmscolorectal cancer
Category:MeSHDisease Ontology
Type:Neoplasms//Digestive System Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.A large intestine cancer that is located_in the colon and/or located_in the rectum.
Alias:Colorectal Cancer//Colorectal Carcinoma//Colorectal Tumors//Neoplasms, ColorectalN/A



Disease Association Statistics

Total Associated tsRNA Number:195
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:N/A
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:36527118
Disease Name:Colorectal Neoplasms
Tissue:Colon
Dysfunction Pattern:Up-Regulation
Validated Method:High-throughput sequencing
Description:Three tRFs (tRF-3022b, tRF-3030b and tRF-5008b) showed an increasing trend in CRC tissues compared to adjacent normal tissues. They also tended to be elevated in plasma exosomes of CRC patients compared to healthy controls.
Comparision:Cancer VS Normal
Mechanism:Notably, we found that the decrease in the three tRFs arrests the progression of the CRC cell cycle and induces cell apoptosis. Silencing tRF-3022b could facilitate M2 macrophage polarization. Mechanistically, we found that tRF-3022b binds to galectin 1 (LGALS1) and macrophage migration inhibitory factor (MIF) in CRC cells and reduces polarization by regulating MIF in M2 macrophages.