Entry Detail



General Information

Database ID:TRD03413
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF5-GlyGCC
tsRNA Type:tRF-5
Amino acid and Anticodon:GlyGCC
Sequence:N/A
Related Target:N/A
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:9
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D018357 DOID:1273
Disease Name:Respiratory Syncytial Virus Infectionsrespiratory syncytial virus infectious disease
Category:MeSHDisease Ontology
Type:Infectionsdisease by infectious agent
Define:Pneumovirus infections caused by the RESPIRATORY SYNCYTIAL VIRUSES. Humans and cattle are most affected but infections in goats and sheep have been reported.A viral infectious disease that results_in infection located_in upper respiratory tract or located_in lower respiratory tract, has_material_basis_in Human respiratory syncytial virus, which is transmitted_by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted_by contaminated fomites. The infection has_symptom runny nose, has_symptom fever, has_symptom cough, has_symptom wheezing, and has_symptom respiratory distress.
Alias:Infections, Respiratory Syncytial Virus//Respiratory Syncytial Virus Infectionrespiratory syncytial virus//RSV



Disease Association Statistics

Total Associated tsRNA Number:25
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:Northern blot
Weak Evidence:N/A



Reference

[1] PubMed ID:32245206
Disease Name:Respiratory Syncytial Virus Infections
Tissue:N/A
Dysfunction Pattern:N/A
Validated Method:Northern blot
Description:Similar to tRF5-GluCTC, both tRF5-GlyGCC and tRF6-LysCTT also favor the RSV replication and contribute to RSV-induced inflammation. Their induction is also ANG dependent and exclusively happens in the cytoplasmic compartment.
Comparision:N/A
Mechanism:In summary, RSV uses induced tRF5-GluCTC to suppress the APOER2 expression, allowing more P proteins available for the RdRp formation to promote RSV replication (Figure 4) [97]. Similar to tRF5-GluCTC, both tRF5-GlyGCC and tRF5-LysCTT also favor the RSV replication and contribute to RSV-induced inflammation. Their induction is also ANG-dependent and exclusively happens in the cytoplasmic compartment [96].