Entry Detail


General Information

Database ID:TRD03215
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-23-87R8WP9IY
tsRNA Type:tRF-5
Amino acid and Anticodon:GluTTC
Sequence:TCCCTGGTGGTCTAGTGGCTAGG
Related Target:N/A
Predicted Target:TFCP2L1//TUBA1B//EPN2//CDC42BPG//INSYN1//JSRP1//DECR2//ARMCX4//KLHL38//TNFSF12
External Links:
MINTbase ID:tRF-23-87R8WP9IY
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Glu-TTC-8-1
Anticodon:GluTTC
tRNA_number:trna94
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 149664405        End Site(bp): 149664427

[2] gtRNAdb_ID:tRNA-Glu-TTC-4-1
Anticodon:GluTTC
tRNA_number:trna134
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 16861823        End Site(bp): 16861845

[3] gtRNAdb_ID:tRNA-Glu-TTC-4-2
Anticodon:GluTTC
tRNA_number:trna84
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161391932        End Site(bp): 161391954

[4] gtRNAdb_ID:tRNA-Glu-TTC-3-1
Anticodon:GluTTC
tRNA_number:trna5
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 17199078        End Site(bp): 17199100



tsRNA Association Statistics

Total Associated Disease Number:9
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D014648DOID:799
Disease Name:Varicose Veinsvaricose veins
Category:MeSHDisease Ontology
Type:Cardiovascular Diseasesdisease of anatomical entity
Define:Enlarged and tortuous VEINS.A vein disease that is characterized by swollen, twisted veins visible just under the surface of the skin.
Alias:Varices//Varixvarices//Varix//Venous ectasia//Venous varices



Disease Association Statistics

Total Associated tsRNA Number:16
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:31432124
Disease Name:Varicose Veins
Tissue:Vascular Tissue
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:N/A
Comparision:Disease VS Control
Mechanism:Two upregulated tRFs (tRF-36-F900BY4D84KRIME and tRF-23-87R8WP9IY) and one downregulated tRF (tRF-40-86J8WPMN1E8Y7Z2R) were further validated by RT-qPCR, and a signaling pathway regulation network of their target genes confirmed their involvement in the calcium, Wnt and MAPK signaling pathways.