Entry Detail


General Information

Database ID:TRD03154
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-Glu-CTC-003
tsRNA Type:tRF-5
Amino acid and Anticodon:GluCTC
Sequence:TCCCTGGTGGTCTAGT
Related Target:AKT1; MYD88
Predicted Target:SLC39A13//TFCP2L1//SMAD3//COL6A6//DAB2IP//NDOR1//QSER1//CC2D2A//MUC4//RP1
External Links:
MINTbase ID:tRF-16-87R8WPE
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Glu-CTC-2-1
Anticodon:GluCTC
tRNA_number:trna59
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 249168447        End Site(bp): 249168462

[2] gtRNAdb_ID:tRNA-Glu-CTC-1-1
Anticodon:GluCTC
tRNA_number:trna116
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 145399289        End Site(bp): 145399304

[3] gtRNAdb_ID:tRNA-Glu-CTC-1-5
Anticodon:GluCTC
tRNA_number:trna71
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161439245        End Site(bp): 161439260

[4] gtRNAdb_ID:tRNA-Glu-CTC-1-4
Anticodon:GluCTC
tRNA_number:trna74
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161431865        End Site(bp): 161431880

[5] gtRNAdb_ID:tRNA-Glu-CTC-1-3
Anticodon:GluCTC
tRNA_number:trna77
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161424454        End Site(bp): 161424469

[6] gtRNAdb_ID:tRNA-Glu-CTC-1-2
Anticodon:GluCTC
tRNA_number:trna80
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161417074        End Site(bp): 161417089

[7] gtRNAdb_ID:tRNA-Glu-CTC-1-6
Anticodon:GluCTC
tRNA_number:trna77
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 28949976        End Site(bp): 28949991

[8] gtRNAdb_ID:tRNA-Glu-CTC-1-7
Anticodon:GluCTC
tRNA_number:trna87
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 126101449        End Site(bp): 126101464

[9] gtRNAdb_ID:tRNA-Glu-TTC-8-1
Anticodon:GluTTC
tRNA_number:trna94
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 149664412        End Site(bp): 149664427

[10] gtRNAdb_ID:tRNA-Glu-TTC-4-1
Anticodon:GluTTC
tRNA_number:trna134
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 16861830        End Site(bp): 16861845

[11] gtRNAdb_ID:tRNA-Glu-TTC-4-2
Anticodon:GluTTC
tRNA_number:trna84
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161391939        End Site(bp): 161391954

[12] gtRNAdb_ID:tRNA-Glu-TTC-3-1
Anticodon:GluTTC
tRNA_number:trna5
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 17199078        End Site(bp): 17199093



tsRNA Association Statistics

Total Associated Disease Number:7
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D001943DOID:1612
Disease Name:Breast Neoplasmsbreast cancer
Category:MeSHDisease Ontology
Type:Neoplasms//Skin and Connective Tissue Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:Tumors or cancer of the human BREAST.A thoracic cancer that originates in the mammary gland.
Alias:Breast Cancer//Breast Carcinoma//Breast Tumors//Cancer of Breast//Cancer of the Breast//Human Mammary Carcinoma//Malignant Neoplasm of Breast//Malignant Tumor of Breast//Mammary Cancer//Mammary Carcinoma, Human//Mammary Neoplasm, Human//Mammary Neoplasms, Human//Neoplasms, Breast//Tumors, Breastbreast tumor//malignant neoplasm of breast//malignant tumor of the breast//mammary cancer//mammary neoplasm//mammary tumor//primary breast cancer



Disease Association Statistics

Total Associated tsRNA Number:549
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:32814252
Disease Name:Breast Neoplasms
Tissue:Plasma
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:Thirty tRFs and tiRNAs were selected by high-throughput sequencing in screening phase and then assessed in training, testing, and external validation phases byqRT-PCR. Six tRFs (tRF-Glu-CTC-003, tRF-Gly-CCC-007, tRF-Gly-CCC-008, tRF-Leu-CAA-003, tRF-Ser-TGA-001, and tRF-Ser-TGA-002) were found significantly downregulated in plasma samples of patients with EBC compared with normal controls.
Comparision:Cancer VS Normal
Mechanism:It was primarily intracellular and involved in biosynthetic and catabolic processes.