Entry Detail


General Information

Database ID:TRD03100
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-24-V29K9UV3IU
tsRNA Type:tRF-5
Amino acid and Anticodon:GlnTTG
Sequence:TAGGATGGGGTGTGATAGGTGGCA
Related Target:GPR78
Predicted Target:VSIG10L//KRBA1//ZNF831//SLC16A5//VAC14//IGF2BP1//NRP2//SLC26A9//YWHAE//PCNX1
External Links:
MINTbase ID:tRF-24-V29K9UV3IU
tRFdb ID:N/A

[1] gtRNAdb_ID:-
Anticodon:GlnTTG
tRNA_number:trnaMT
Chromosome:MT
Strand:-
Coordinate:Start Site(bp): 4377        End Site(bp): 4400

[2] gtRNAdb_ID:-
Anticodon:GlnTTG
tRNA_number:trnalookalike2
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 564927        End Site(bp): 564950



tsRNA Association Statistics

Total Associated Disease Number:2
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D013274 DOID:10534
Disease Name:Stomach Neoplasmsstomach cancer
Category:MeSHDisease Ontology
Type:Neoplasms//Digestive System Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:Tumors or cancer of the STOMACH.A gastrointestinal system cancer that is located_in the stomach.
Alias:Cancer of Stomach//Cancer of the Stomach//Gastric Cancer//Gastric Cancer, Familial Diffuse//Gastric Neoplasms//Neoplasms, Gastric//Neoplasms, Stomach//Stomach Cancergastric cancer//gastric neoplasm



Disease Association Statistics

Total Associated tsRNA Number:79
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:35535309
Disease Name:Stomach Neoplasms
Tissue:Xenograft Mouse Model
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:The tRNA-Derived Fragment tRF-24-V29K9UV3IU Functions as a miRNA-like RNA to Prevent Gastric Cancer Progression by Inhibiting GPR78 Expression.
Comparision:Cancer VS Normal
Mechanism:Functionally, overexpression of tRF-24-V29K9UV3IU significantly suppressed proliferation, migration, and invasion and promoted apoptosis of MKN-45 cells, whereas GPR78 attenuated these effects. Therefore, our data suggest that tRF-24V29K9UV3IU functions as a miRNA-like fragment to suppress GPR78 expression and thus inhibit GC progression. These observations suggest that the tRF-24-V29K9UV3IU/GPR78 axis serves as a potential therapeutic target in GC.