Entry Detail


General Information

Database ID:TRD03078
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-1:30-Gln-CTG-4
tsRNA Type:tRF-5
Amino acid and Anticodon:GlnCTG
Sequence:GGTTCCATGGTGTAATGGTGAGCACTCTGG
Related Target:N/A
Predicted Target:NEFL//SNAPC2//XIRP1//RASSF8//FAM92B//HAGH//SLC26A1//MTSS1//CDH26//PDGFRB
External Links:
MINTbase ID:tRF-30-R9J89O94F5W8
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Gln-CTG-3-1
Anticodon:GlnCTG
tRNA_number:trna15
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 145963304        End Site(bp): 145963333

[2] gtRNAdb_ID:tRNA-Gln-CTG-3-2
Anticodon:GlnCTG
tRNA_number:trna19
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 147505038        End Site(bp): 147505067



tsRNA Association Statistics

Total Associated Disease Number:4
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D003928N/A
Disease Name:Diabetic NephropathiesN/A
Category:MeSHDisease Ontology
Type:Urogenital Diseases//Endocrine System DiseasesN/A
Define:KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.N/A
Alias:Diabetic Glomerulosclerosis//Diabetic Kidney Disease//Diabetic Nephropathy//Glomerulosclerosis, Diabetic//Intracapillary//Glomerulosclerosis//Kimmelstiel-Wilson Disease//Kimmelstiel-Wilson Syndrome//Nodular GlomerulosclerosisN/A



Disease Association Statistics

Total Associated tsRNA Number:29
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR//Transfection//Western blot
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:36561608
Disease Name:Diabetic Nephropathies
Tissue:Kidney
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR//Transfection//Western blot//High-throughput sequencing
Description:Ten selected tRFs with the greatest difference (fold change >2; P<0.05) were verified to be consistent with small RNA-Sequencing data, of which tRF-1:30-Gln-CTG-4 showed the most pronounced difference in expression and was significantly decreased in response to HG.
Comparision:HG VS Normal
Mechanism:In conclusion, the present study discovered that tRFs, which are novel types of sncRNAs, are associated with TIF and involved in DN. The underlying mechanism may involve the dysregulation of autophagy and the FoxO, mTOR and MAPK signalling pathways.