Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of HEAVY METALS. Acute and chronic exposures can cause ANEMIA; KIDNEY and LIVER damage; PULMONARY EDEMA; MEMORY LOSS and behavioral changes; bone deformities in children; and MISCARRIAGE or PREMATURE LABOR in pregnant women.
A549 Cells (Human Alveolar Type Ii-Like Epithelial Cells)
Dysfunction Pattern:
Up-Regulation
Validated Method:
RT-PCR//High-throughput sequencing
Description:
We identified that p65, an important transcription factor belonging to NF-κB family and also a key factor controlling inflammatory gene expression, is a regulated target of a tRF derived from 5'-end of mature tRNA encoding AlaCGC (tRF5-AlaCGC).
Comparision:
Treatment VS Control
Mechanism:
tRF5AlaCGC activates p65, subsequently leading to enhanced secretion of IL-8 in arsenite response.