Entry Detail


General Information

Database ID:TRD02970
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF5-AlaCGC
tsRNA Type:tRF-5
Amino acid and Anticodon:AlaCGC
Sequence:GGGGGTGTAGCTCAGTGGTAGAGCGCGTGC
Related Target:N/A
Predicted Target:TPM1//NPHP4//GPR84//RPAP1//WNT11//CCDC141//TRRAP//AC068580.4//PTCH1//CTSD
External Links:
MINTbase ID:tRF-30-RK9P4P9L5HMV
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Ala-AGC-7-1
Anticodon:AlaAGC
tRNA_number:trna68
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 28687481        End Site(bp): 28687510

[2] gtRNAdb_ID:tRNA-Ala-AGC-5-1
Anticodon:AlaAGC
tRNA_number:trna67
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 28678366        End Site(bp): 28678395

[3] gtRNAdb_ID:tRNA-Ala-AGC-3-1
Anticodon:AlaAGC
tRNA_number:trna65
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 28574933        End Site(bp): 28574962

[4] gtRNAdb_ID:tRNA-Ala-AGC-2-2
Anticodon:AlaAGC
tRNA_number:trna101
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 28831504        End Site(bp): 28831533

[5] gtRNAdb_ID:tRNA-Ala-AGC-2-1
Anticodon:AlaAGC
tRNA_number:trna102
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 28806263        End Site(bp): 28806292

[6] gtRNAdb_ID:tRNA-Ala-CGC-4-1
Anticodon:AlaCGC
tRNA_number:trna70
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 28697092        End Site(bp): 28697121



tsRNA Association Statistics

Total Associated Disease Number:2
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D003928N/A
Disease Name:Diabetic NephropathiesN/A
Category:MeSHDisease Ontology
Type:Urogenital Diseases//Endocrine System DiseasesN/A
Define:KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.N/A
Alias:Diabetic Glomerulosclerosis//Diabetic Kidney Disease//Diabetic Nephropathy//Glomerulosclerosis, Diabetic//Intracapillary//Glomerulosclerosis//Kimmelstiel-Wilson Disease//Kimmelstiel-Wilson Syndrome//Nodular GlomerulosclerosisN/A



Disease Association Statistics

Total Associated tsRNA Number:29
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:37273759
Disease Name:Diabetic Nephropathies
Tissue:Serum samples
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:Ultimately, six differentially expressed (DE) tRFs were identified (P<0.05; |log2fold change| ≥1), including three upregulated (tRF5-GluCTC, tRF5-AlaCGC and tRF5-ValCAC) and three downregulated tRFs (tRF5-GlyCCC, tRF3-GlyGCC and tRF3-IleAAT).
Comparision:DN VS Diabetes Mellitus
Mechanism:In conclusion, GO analysis suggested that the DE tRFs may be associated with DN pathology.