Entry Detail


General Information

Database ID:TRD02960
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-16-RKVP4P0
tsRNA Type:tRF-5
Amino acid and Anticodon:AlaAGC;CysGCA;TyrGTA
Sequence:GGGGGTATAGCTCAGG
Related Target:N/A
Predicted Target:PRKDC//UBA52//MDM4//CYP2C8//TRPM1//CARMIL3//CYP2C18//AL583836.1//CYP2C19//CYP2C9
External Links:
MINTbase ID:tRF-16-RKVP4P0
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Ala-AGC-23-1
Anticodon:AlaAGC
tRNA_number:trna111
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 28746600        End Site(bp): 28746615

[2] gtRNAdb_ID:tRNA-Cys-GCA-19-1
Anticodon:CysGCA
tRNA_number:trna18
Chromosome:7
Strand:-
Coordinate:Start Site(bp): 149310212        End Site(bp): 149310227

[3] gtRNAdb_ID:tRNA-Cys-GCA-16-1
Anticodon:CysGCA
tRNA_number:trna7
Chromosome:7
Strand:+
Coordinate:Start Site(bp): 149243631        End Site(bp): 149243646

[4] gtRNAdb_ID:tRNA-Cys-GCA-15-1
Anticodon:CysGCA
tRNA_number:trna10
Chromosome:7
Strand:+
Coordinate:Start Site(bp): 149281816        End Site(bp): 149281831

[5] gtRNAdb_ID:tRNA-Cys-GCA-14-1
Anticodon:CysGCA
tRNA_number:trna29
Chromosome:17
Strand:-
Coordinate:Start Site(bp): 37017993        End Site(bp): 37018008

[6] gtRNAdb_ID:tRNA-Cys-GCA-13-1
Anticodon:CysGCA
tRNA_number:trna25
Chromosome:7
Strand:-
Coordinate:Start Site(bp): 149052822        End Site(bp): 149052837

[7] gtRNAdb_ID:tRNA-Cys-GCA-10-1
Anticodon:CysGCA
tRNA_number:trna22
Chromosome:7
Strand:-
Coordinate:Start Site(bp): 149074657        End Site(bp): 149074672

[8] gtRNAdb_ID:tRNA-Cys-GCA-9-1
Anticodon:CysGCA
tRNA_number:trna6
Chromosome:3
Strand:-
Coordinate:Start Site(bp): 131950698        End Site(bp): 131950713

[9] gtRNAdb_ID:tRNA-Cys-GCA-9-3
Anticodon:CysGCA
tRNA_number:trna13
Chromosome:7
Strand:+
Coordinate:Start Site(bp): 149332778        End Site(bp): 149332793

[10] gtRNAdb_ID:tRNA-Cys-GCA-9-4
Anticodon:CysGCA
tRNA_number:trna15
Chromosome:7
Strand:+
Coordinate:Start Site(bp): 149404760        End Site(bp): 149404775

[11] gtRNAdb_ID:tRNA-Cys-GCA-9-2
Anticodon:CysGCA
tRNA_number:trna6
Chromosome:7
Strand:+
Coordinate:Start Site(bp): 149028220        End Site(bp): 149028235

[12] gtRNAdb_ID:tRNA-Cys-GCA-8-1
Anticodon:CysGCA
tRNA_number:trna8
Chromosome:14
Strand:+
Coordinate:Start Site(bp): 73429679        End Site(bp): 73429694

[13] gtRNAdb_ID:tRNA-Cys-GCA-7-1
Anticodon:CysGCA
tRNA_number:trna127
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 93981891        End Site(bp): 93981906

[14] gtRNAdb_ID:tRNA-Cys-GCA-3-1
Anticodon:CysGCA
tRNA_number:trna20
Chromosome:7
Strand:-
Coordinate:Start Site(bp): 149286220        End Site(bp): 149286235

[15] gtRNAdb_ID:tRNA-Tyr-GTA-10-1
Anticodon:TyrGTA
tRNA_number:trna9
Chromosome:7
Strand:+
Coordinate:Start Site(bp): 149255133        End Site(bp): 149255148



tsRNA Association Statistics

Total Associated Disease Number:1
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D015451DOID:1040
Disease Name:Leukemia, Lymphocytic, Chronic, B-Cellchronic lymphocytic leukemia
Category:MeSHDisease Ontology
Type:Neoplasms//Hemic and Lymphatic Diseases//Immune System Diseases//Pathological Conditions, Signs and Symptomsdisease of anatomical entity//disease of cellular proliferation
Define:A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.A lymphocytic leukemia characterized by over production of B-cells and their accumulation in bone marrow and blood.
Alias:B-Cell Chronic Lymphocytic Leukemia//B-Cell Leukemia, Chronic//B-Cell Malignancy, Low-Grade//B-Lymphocytic Leukemia, Chronic//Chronic Lymphocytic Leukemia//Diffuse Well-Differentiated Lymphocytic Lymphoma//Disrupted In B-Cell Malignancy//Leukemia, B Cell, Chronic//Leukemia, B-Cell, Chronic//Leukemia, Chronic Lymphatic//Leukemia, Chronic Lymphocytic//Leukemia, Chronic Lymphocytic, B-Cell//Leukemia, Lymphoblastic, Chronic//Leukemia, Lymphocytic, Chronic//Leukemia, Lymphocytic, Chronic, B Cell//Lymphoblastic Leukemia, Chronic//Lymphocytic Leukemia, Chronic//Lymphocytic Leukemia, Chronic, B Cell//Lymphocytic Leukemia, Chronic, B-Cell//Lymphocytic Lymphoma//Lymphocytic Lymphoma, Diffuse, Well Differentiated//Lymphocytic Lymphoma, Diffuse, Well-Differentiated//Lymphocytic Lymphoma, Well Differentiated//Lymphocytic Lymphoma, Well-Differentiated//Lymphoma, Lymphocytic//Lymphoma, Lymphocytic, Diffuse, Well Differentiated//Lymphoma, Lymphocytic, Diffuse, Well-Differentiated//Lymphoma, Lymphocytic, Well Differentiated//Lymphoma, Lymphocytic, Well-Differentiated//Lymphoma, Lymphoplasmacytoid, CLL//Lymphoma, Small Lymphocytic//Lymphoma, Small Lymphocytic, Plasmacytoid//Lymphoma, Small-Cell//Lymphoplasmacytoid Lymphoma, CLL//Small-Cell LymphomaB-cell chronic lymphocytic leukaemia//B-cell chronic lymphocytic leukemia//B-cell chronic lymphoid leukemia//chronic lymphatic leukaemia//chronic lymphatic leukemia//chronic lymphocytic leukaemia//CLL//lymphoplasmacytic leukaemia//lymphoplasmacytic leukemia



Disease Association Statistics

Total Associated tsRNA Number:1731
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:31723042
Disease Name:Leukemia, Lymphocytic, Chronic, B-Cell
Tissue:B Cells
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:N/A
Comparision:CLL VS Normal
Mechanism:We further analyzed the expression of mature tRFs and found that mature tRFs are drastically dysregulated in CLL. Thus, we conclude that tsRNAs and mature tRFs, 2 classes of small noncoding RNAs, may be associated with the development of CLL.