Entry Detail


General Information

Database ID:TRD02882
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF/miR-1280
tsRNA Type:tRF-3
Amino acid and Anticodon:N/A
Sequence:AGGGTGGCGACGGT
Related Target:JAG2
Predicted Target:EGLN2//DMRT3//PHETA1//AGO3//GARS//EVI5L//NRF1//MRPL2//TSC22D2//CAV1
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:5
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D015179DOID:9256
Disease Name:Colorectal Neoplasmscolorectal cancer
Category:MeSHDisease Ontology
Type:Neoplasms//Digestive System Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.A large intestine cancer that is located_in the colon and/or located_in the rectum.
Alias:Colorectal Cancer//Colorectal Carcinoma//Colorectal Tumors//Neoplasms, ColorectalN/A



Disease Association Statistics

Total Associated tsRNA Number:195
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:Northern blot
Weak Evidence:N/A



Reference

[1] PubMed ID:28446464
Disease Name:Colorectal Neoplasms
Tissue:Colorectal Cancer
Dysfunction Pattern:Up-Regulation
Validated Method:Northern blot
Description:tRF/miR-1280 expression was decreased in human specimens of colorectal cancer.
Comparision:Cancer VS Normal
Mechanism:tRF/miR-1280-mediated inactivation of Notch signaling suppressed CSC phenotypes, including by direct transcriptional repression of the Gata1/3 and miR-200b genes.

[2] PubMed ID:34837147
Disease Name:Colorectal Neoplasms
Tissue:Colorectal Cancer
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR
Description:The three tRFs derived from tRF/miR-1280, tRNA-ValAAC/CAC , and tRNA-AspGTC downregulated in tumor tissues.
Comparision:Cancer VS Normal
Mechanism:N/A