Entry Detail


General Information

Database ID:TRD02881
Confidence:Median
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF/miR-1280
tsRNA Type:tRF-3
Amino acid and Anticodon:N/A
Sequence:AGGGTGGCGACGGT
Related Target:N/A
Predicted Target:EGLN2//DMRT3//PHETA1//AGO3//GARS//EVI5L//NRF1//MRPL2//TSC22D2//CAV1
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:5
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D001943DOID:1612
Disease Name:Breast Neoplasmsbreast cancer
Category:MeSHDisease Ontology
Type:Neoplasms//Skin and Connective Tissue Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:Tumors or cancer of the human BREAST.A thoracic cancer that originates in the mammary gland.
Alias:Breast Cancer//Breast Carcinoma//Breast Tumors//Cancer of Breast//Cancer of the Breast//Human Mammary Carcinoma//Malignant Neoplasm of Breast//Malignant Tumor of Breast//Mammary Cancer//Mammary Carcinoma, Human//Mammary Neoplasm, Human//Mammary Neoplasms, Human//Neoplasms, Breast//Tumors, Breastbreast tumor//malignant neoplasm of breast//malignant tumor of the breast//mammary cancer//mammary neoplasm//mammary tumor//primary breast cancer



Disease Association Statistics

Total Associated tsRNA Number:549
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:N/A



Reference

[1] PubMed ID:25179838
Disease Name:Breast Neoplasms
Tissue:Breast Cancer Tissue And Blood
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR
Description:We confirmed that miR-1280 was not a classic microRNA, but a tRNALeu-derived fragment. These findings suggest that a circulating tRNA-derived microRNA, miR1280, is differently expressed in breast cancer patients and may serve as a biomarker for ER-positive breast cancer.
Comparision:Cancer VS Normal
Mechanism:Expression of miR-1280,a tRNA-derived microRNA, was detected in blood samples from ER-positive breast cancer patients;this expression may serve as a biomarker that reflects treatment response.