Entry Detail


General Information

Database ID:TRD02869
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-Val-TAC-023
tsRNA Type:tRF-3
Amino acid and Anticodon:ValTAC
Sequence:AACTTACACTTAGG
Related Target:TPRG1L
Predicted Target:KIF18A//AFG1L//FAM53C//TRANK1//SERPINB8//RNF144B//C21orf58//CRTC1//UBE2D2//OOSP4A
External Links:
MINTbase ID:tRF-20-01WZ03O6
tRFdb ID:tRFdb-3013b



tsRNA Association Statistics

Total Associated Disease Number:16
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D005706DOID:3121
Disease Name:Gallbladder Neoplasmsgallbladder cancer
Category:MeSHDisease Ontology
Type:Neoplasms//Digestive System Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:Tumors or cancer of the gallbladder.A biliary tract cancer that is located_in the gallbladder.
Alias:Cancer of Gallbladder//Cancer of the Gallbladder//Gall Bladder Cancer//Gallbladder Cancer//Neoplasms, Gallbladdergallbladder Ca//gallbladder neoplasm//localized malignant gallbladder neoplasm//malignant neoplasm of gallbladder//malignant tumor of the gallbladder//malignant tumour of gallbladder tumor of the gallbladder [EXACT]



Disease Association Statistics

Total Associated tsRNA Number:42
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:36401185
Disease Name:Gallbladder Neoplasms
Tissue:Gallbladder Cancer
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:tRF-3013b was significantly downregulated in GBC compared with paracancer tissues. Decreased expression of tRF-3013b in GBC patients was correlated with poor overall survival.
Comparision:Cancer VS Normal
Mechanism:Functional experiments demonstrated that tRF-3013b inhibited GBC cell proliferation and induced cell-cycle arrest. Mechanically, tRF-3013b exerted RNA silencing effect on TPRG1L by binding to AGO3, and then inhibited NF-κB.