| [1] PubMed ID: | 35585048 |
| Disease Name: | Stomach Neoplasms |
| Tissue: | Stomach |
| Dysfunction Pattern: | Up-Regulation |
| Validated Method: | PCR//High-throughput sequencing |
| Description: | Here, we aimed to explore the carcinogenic roles of tRFs and tiRNAs in GC with RNA-Sequencing technique, and found a novel 3’tRNA-derived fragment tRF-Val was significantly upregulated in GC tissues and cell lines. |
| Comparision: | Cancer VS Normal |
| Mechanism: | tRF-Val expression was positively correlated with tumor size and the depth of tumor invasion in GC tissues. Functionally, tRF-Val promoted proliferation and invasion, and inhibited apoptosis in GC cells. Mechanistically, tRF-Val directly bound to the chaperone molecule EEF1A1, mediated its transport into the nucleus and promoted its interaction with MDM2 (a specific p53 E3 ubiquitin ligase), thus inhibiting the downstream molecular pathway of p53 and promoting GC progression. |
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