Entry Detail


General Information

Database ID:TRD02753
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-25-R9ODMJ6B26
tsRNA Type:tRF-3
Amino acid and Anticodon:ValAAC;ValCAC
Sequence:GGTTCGAAACCGGGCGGAAACACCA
Related Target:N/A
Predicted Target:HECTD4//LTBP3//MTURN//RMND5A//ESR1//STK32A//MYO1G//ERAP1//MOV10//GNG2
External Links:
MINTbase ID:tRF-25-R9ODMJ6B26
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Val-AAC-4-1
Anticodon:ValAAC
tRNA_number:trna136
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 27648885-3        End Site(bp): 27648906

[2] gtRNAdb_ID:tRNA-Val-AAC-2-1
Anticodon:ValAAC
tRNA_number:trna15
Chromosome:5
Strand:-
Coordinate:Start Site(bp): 180615416-3        End Site(bp): 180615437

[3] gtRNAdb_ID:tRNA-Val-AAC-1-1
Anticodon:ValAAC
tRNA_number:trna2
Chromosome:3
Strand:+
Coordinate:Start Site(bp): 169490069        End Site(bp): 169490090+3

[4] gtRNAdb_ID:tRNA-Val-AAC-1-4
Anticodon:ValAAC
tRNA_number:trna12
Chromosome:5
Strand:-
Coordinate:Start Site(bp): 180645270-3        End Site(bp): 180645291

[5] gtRNAdb_ID:tRNA-Val-AAC-1-2
Anticodon:ValAAC
tRNA_number:trna4
Chromosome:5
Strand:+
Coordinate:Start Site(bp): 180591205        End Site(bp): 180591226+3

[6] gtRNAdb_ID:tRNA-Val-AAC-1-3
Anticodon:ValAAC
tRNA_number:trna5
Chromosome:5
Strand:+
Coordinate:Start Site(bp): 180596661        End Site(bp): 180596682+3

[7] gtRNAdb_ID:tRNA-Val-AAC-1-5
Anticodon:ValAAC
tRNA_number:trna132
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 27721179-3        End Site(bp): 27721200

[8] gtRNAdb_ID:tRNA-Val-CAC-5-1
Anticodon:ValCAC
tRNA_number:trna90
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 149684088-3        End Site(bp): 149684109

[9] gtRNAdb_ID:tRNA-Val-CAC-1-1
Anticodon:ValCAC
tRNA_number:trna85
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161369490-3        End Site(bp): 161369511

[10] gtRNAdb_ID:tRNA-Val-CAC-1-5
Anticodon:ValCAC
tRNA_number:trna10
Chromosome:5
Strand:-
Coordinate:Start Site(bp): 180649395-3        End Site(bp): 180649416

[11] gtRNAdb_ID:tRNA-Val-CAC-1-3
Anticodon:ValCAC
tRNA_number:trna18
Chromosome:5
Strand:-
Coordinate:Start Site(bp): 180529253-3        End Site(bp): 180529274

[12] gtRNAdb_ID:tRNA-Val-CAC-1-2
Anticodon:ValCAC
tRNA_number:trna2
Chromosome:5
Strand:+
Coordinate:Start Site(bp): 180524121        End Site(bp): 180524142+3

[13] gtRNAdb_ID:tRNA-Val-CAC-1-4
Anticodon:ValCAC
tRNA_number:trna6
Chromosome:5
Strand:+
Coordinate:Start Site(bp): 180600701        End Site(bp): 180600722+3

[14] gtRNAdb_ID:tRNA-Val-CAC-1-6
Anticodon:ValCAC
tRNA_number:trna9
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 26538333        End Site(bp): 26538354+3



tsRNA Association Statistics

Total Associated Disease Number:8
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D010024DOID:11476
Disease Name:Osteoporosisosteoporosis
Category:MeSHDisease Ontology
Type:Musculoskeletal Diseases//Nutritional and Metabolic Diseasesdisease of anatomical entity
Define:Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.A bone resorption disease characterized by decreased density of normally mineralized bone which results_in the thinning of bone tissue and decreased mechanical strength.
Alias:Age-Related Osteoporosis//Bone Loss, Age-Related//Osteoporosis, Age-Related//Osteoporosis, Involutional//Osteoporosis, Post-Traumatic//Osteoporosis, Senile//Senile OsteoporosisN/A



Disease Association Statistics

Total Associated tsRNA Number:73
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:30345646
Disease Name:Osteoporosis
Tissue:Plasma
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:Our results suggest that plasma exosomal tRF‐25, tRF‐38 and tRF‐18 might be diagnostic biomarkers for osteoporosis detection.
Comparision:Disease VS Control
Mechanism:Higher expression levels of plasma exosomal tRF‐25‐R9ODMJ6B26 (tRF‐25), tRF‐38‐QB1MK8YUBS68BFD2 (tRF‐38), tRF‐18‐BS68BFD2 (tRF‐18) in osteoporosis were confirmed by qPCR. Plasma exosomal tRF‐25, tRF‐38 and tRF‐18 showed better accuracy for osteoporosis diagnosis.