Entry Detail


General Information

Database ID:TRD02747
Confidence:Median
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-Val-AAC-003
tsRNA Type:tRF-3
Amino acid and Anticodon:ValAAC
Sequence:ACCGGGCGGAAACACCA
Related Target:N/A
Predicted Target:STK32A//LTBP3//ITGB3BP//CDYL//SH3BP5L//DNAJC5//LPO//LYPLA1//HNRNPH1//TPD52L2
External Links:
MINTbase ID:tRF-17-08Q2B52
tRFdb ID:tRFdb-3008a

[1] gtRNAdb_ID:tRNA-Val-AAC-4-1
Anticodon:ValAAC
tRNA_number:trna136
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 27648885-3        End Site(bp): 27648898

[2] gtRNAdb_ID:tRNA-Val-AAC-2-1
Anticodon:ValAAC
tRNA_number:trna15
Chromosome:5
Strand:-
Coordinate:Start Site(bp): 180615416-3        End Site(bp): 180615429

[3] gtRNAdb_ID:tRNA-Val-AAC-1-1
Anticodon:ValAAC
tRNA_number:trna2
Chromosome:3
Strand:+
Coordinate:Start Site(bp): 169490077        End Site(bp): 169490090+3

[4] gtRNAdb_ID:tRNA-Val-AAC-1-4
Anticodon:ValAAC
tRNA_number:trna12
Chromosome:5
Strand:-
Coordinate:Start Site(bp): 180645270-3        End Site(bp): 180645283

[5] gtRNAdb_ID:tRNA-Val-AAC-1-2
Anticodon:ValAAC
tRNA_number:trna4
Chromosome:5
Strand:+
Coordinate:Start Site(bp): 180591213        End Site(bp): 180591226+3

[6] gtRNAdb_ID:tRNA-Val-AAC-1-3
Anticodon:ValAAC
tRNA_number:trna5
Chromosome:5
Strand:+
Coordinate:Start Site(bp): 180596669        End Site(bp): 180596682+3

[7] gtRNAdb_ID:tRNA-Val-AAC-1-5
Anticodon:ValAAC
tRNA_number:trna132
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 27721179-3        End Site(bp): 27721192

[8] gtRNAdb_ID:tRNA-Val-CAC-5-1
Anticodon:ValCAC
tRNA_number:trna90
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 149684088-3        End Site(bp): 149684101

[9] gtRNAdb_ID:tRNA-Val-CAC-1-1
Anticodon:ValCAC
tRNA_number:trna85
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161369490-3        End Site(bp): 161369503

[10] gtRNAdb_ID:tRNA-Val-CAC-1-5
Anticodon:ValCAC
tRNA_number:trna10
Chromosome:5
Strand:-
Coordinate:Start Site(bp): 180649395-3        End Site(bp): 180649408

[11] gtRNAdb_ID:tRNA-Val-CAC-1-3
Anticodon:ValCAC
tRNA_number:trna18
Chromosome:5
Strand:-
Coordinate:Start Site(bp): 180529253-3        End Site(bp): 180529266

[12] gtRNAdb_ID:tRNA-Val-CAC-1-2
Anticodon:ValCAC
tRNA_number:trna2
Chromosome:5
Strand:+
Coordinate:Start Site(bp): 180524129        End Site(bp): 180524142+3

[13] gtRNAdb_ID:tRNA-Val-CAC-1-4
Anticodon:ValCAC
tRNA_number:trna6
Chromosome:5
Strand:+
Coordinate:Start Site(bp): 180600709        End Site(bp): 180600722+3

[14] gtRNAdb_ID:tRNA-Val-CAC-1-6
Anticodon:ValCAC
tRNA_number:trna9
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 26538341        End Site(bp): 26538354+3



tsRNA Association Statistics

Total Associated Disease Number:3
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D009914DOID:5773
Disease Name:Oral Submucous Fibrosisoral submucous fibrosis
Category:MeSHDisease Ontology
Type:Stomatognathic Diseasesdisease of anatomical entity
Define:Irreversible FIBROSIS of the submucosal tissue of the MOUTH.A mouth disease that is characterized by juxta-epithelial inflammatory reaction and progressive fibrosis of the submucosal tissues.
Alias:N/AOral cavity Submucous Fibrosis//Oral submucosal fibrosis//Oral submucosal fibrosis, including of tongue



Disease Association Statistics

Total Associated tsRNA Number:126
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:N/A
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:34558114
Disease Name:Oral Submucous Fibrosis
Tissue:Oral Submucous Fibrosis
Dysfunction Pattern:Down-Regulation
Validated Method:High-throughput sequencing
Description:Of 126 tsRNAs in OSF were dysregulated, including 73 upregulated tsRNAs and 53 downregulated tsRNAs. The downregulated tiRNA-Val-CAC-002,tRF-Asn-GTT-005, tRF-Trp-CCA-007 and upregulated tRF-Gly-TCC-016,tRF-Pro-TGG-009 showed significant differences by qRT-PCR validation.
Comparision:Disease VS Control
Mechanism:tRNA-derived fragments are dysregulated and could be involved in the pathogenesis of oral submucous fibrosis.