Entry Detail


General Information

Database ID:TRD02713
Confidence:Median
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-3030b
tsRNA Type:tRF-3
Amino acid and Anticodon:TyrGTA
Sequence:TCGATTCCGGCTCGAAGGACCA
Related Target:N/A
Predicted Target:KLHDC4//TNR//REPIN1//ARHGAP33//DUS2//GAD2//TTC8//DNMT3A//MDN1//UROC1
External Links:
MINTbase ID:tRF-22-WE884U1D2
tRFdb ID:tRFdb-3030b

[1] gtRNAdb_ID:tRNA-Tyr-GTA-5-3
Anticodon:TyrGTA
tRNA_number:trna19
Chromosome:14
Strand:-
Coordinate:Start Site(bp): 21121258-3        End Site(bp): 21121276

[2] gtRNAdb_ID:tRNA-Tyr-GTA-5-4
Anticodon:TyrGTA
tRNA_number:trna16
Chromosome:14
Strand:-
Coordinate:Start Site(bp): 21131351-3        End Site(bp): 21131369

[3] gtRNAdb_ID:tRNA-Tyr-GTA-5-5
Anticodon:TyrGTA
tRNA_number:trna5
Chromosome:14
Strand:+
Coordinate:Start Site(bp): 21151502        End Site(bp): 21151520+3

[4] gtRNAdb_ID:tRNA-Tyr-GTA-2-1
Anticodon:TyrGTA
tRNA_number:trna2
Chromosome:2
Strand:+
Coordinate:Start Site(bp): 27273720        End Site(bp): 27273738+3

[5] gtRNAdb_ID:tRNA-Tyr-GTA-5-1
Anticodon:TyrGTA
tRNA_number:trna4
Chromosome:8
Strand:+
Coordinate:Start Site(bp): 67025676        End Site(bp): 67025694+3

[6] gtRNAdb_ID:tRNA-Tyr-GTA-5-2
Anticodon:TyrGTA
tRNA_number:trna5
Chromosome:8
Strand:+
Coordinate:Start Site(bp): 67026293        End Site(bp): 67026311+3



tsRNA Association Statistics

Total Associated Disease Number:1
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D015179DOID:9256
Disease Name:Colorectal Neoplasmscolorectal cancer
Category:MeSHDisease Ontology
Type:Neoplasms//Digestive System Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.A large intestine cancer that is located_in the colon and/or located_in the rectum.
Alias:Colorectal Cancer//Colorectal Carcinoma//Colorectal Tumors//Neoplasms, ColorectalN/A



Disease Association Statistics

Total Associated tsRNA Number:195
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:N/A
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:36527118
Disease Name:Colorectal Neoplasms
Tissue:Colon
Dysfunction Pattern:Up-Regulation
Validated Method:High-throughput sequencing
Description:Three tRFs (tRF-3022b, tRF-3030b and tRF-5008b) showed an increasing trend in CRC tissues compared to adjacent normal tissues. They also tended to be elevated in plasma exosomes of CRC patients compared to healthy controls.
Comparision:Cancer VS Normal
Mechanism:Notably, we found that the decrease in the three tRFs arrests the progression of the CRC cell cycle and induces cell apoptosis. Silencing tRF-3022b could facilitate M2 macrophage polarization. Mechanistically, we found that tRF-3022b binds to galectin 1 (LGALS1) and macrophage migration inhibitory factor (MIF) in CRC cells and reduces polarization by regulating MIF in M2 macrophages.