Entry Detail


General Information

Database ID:TRD02700
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-17-88481D2
tsRNA Type:tRF-3
Amino acid and Anticodon:TyrGTA
Sequence:TCCGGCTCGGAGGACCA
Related Target:N/A
Predicted Target:STMN3//CCDC106//C8orf58//EPN2//CLK3//NMRAL1//RNF32//OSCAR//ADAMTS10//PSTPIP1
External Links:
MINTbase ID:tRF-17-88481D2
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Tyr-GTA-3-1
Anticodon:TyrGTA
tRNA_number:trna16
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 26577407        End Site(bp): 26577420+3

[2] gtRNAdb_ID:tRNA-Tyr-GTA-6-1
Anticodon:TyrGTA
tRNA_number:trna17
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 26595177        End Site(bp): 26595190+3



tsRNA Association Statistics

Total Associated Disease Number:10
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D000077195DOID:5520
Disease Name:Squamous Cell Carcinoma of Head and Neckhead and neck squamous cell carcinom
Category:MeSHDisease Ontology
Type:Neoplasmsdisease of cellular proliferation
Define:The most common type of head and neck carcinoma that originates from cells on the surface of the NASAL CAVITY; MOUTH; PARANASAL SINUSES, SALIVARY GLANDS, and LARYNX. Mutations in TNFRSF10B, PTEN, and ING1 genes are associated with this cancer.A head and neck carcinoma that has_material_basis_in squamous cells that line the moist, mucosal surfaces inside the head and neck.
Alias:Carcinoma, Squamous Cell of Head and Neck//HNSCC//Head And Neck Squamous Cell Carcinomas//Head and Neck Squamous Cell Carcinoma//Hypopharyngeal Squamous Cell Carcinoma//Laryngeal Squamous Cell Carcinoma//Oral Cavity Squamous Cell Carcinoma//Oral Squamous Cell Carcinoma//Oral Squamous Cell Carcinomas//Oral Tongue Squamous Cell Carcinoma//Oropharyngeal Squamous Cell Carcinoma//Squamous Cell Carcinoma of Larynx//Squamous Cell Carcinoma of the Head and Neck//Squamous Cell Carcinoma of the Larynx//Squamous Cell Carcinoma of the Mouth//Squamous Cell Carcinoma of the Nasal Cavity//Squamous Cell Carcinoma, Head And Neckcarcinoma of the head and neck//squamous cell carcinoma of the head and neck//squamous cell carcinomas of head and neck



Disease Association Statistics

Total Associated tsRNA Number:38
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:37365531
Disease Name:Squamous Cell Carcinoma of Head and Neck
Tissue:N/A
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:tRFTyr was significantly upregulated in LSCC samples.
Comparision:Cancer VS Normal
Mechanism:Functional assays showed that knockdown of tRFTyr significantly suppressed the progression of LSCC. A series of mechanistic studies revealed that tRFTyr could enhance the phosphorylated level of lactate dehydrogenase A (LDHA) by interacting with it. The activity of LDHA was also activated, which induced lactate accumulation in LSCC cells.