Entry Detail


General Information

Database ID:TRD02671
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-53:70-chrM.Trp-TCA
tsRNA Type:tRF-3
Amino acid and Anticodon:TrpTCA
Sequence:N/A
Related Target:N/A
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:3
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D003928N/A
Disease Name:Diabetic NephropathiesN/A
Category:MeSHDisease Ontology
Type:Urogenital Diseases//Endocrine System DiseasesN/A
Define:KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.N/A
Alias:Diabetic Glomerulosclerosis//Diabetic Kidney Disease//Diabetic Nephropathy//Glomerulosclerosis, Diabetic//Intracapillary//Glomerulosclerosis//Kimmelstiel-Wilson Disease//Kimmelstiel-Wilson Syndrome//Nodular GlomerulosclerosisN/A



Disease Association Statistics

Total Associated tsRNA Number:29
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:36561608
Disease Name:Diabetic Nephropathies
Tissue:Kidney
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:RT-qPCR analysis revealed that tRF-53:70-chrM.Trp-TCA, tRF-49:70-chrM.Trp-TCA, tRF-1:32-Glu-TTC-2 and tRF-1:32-Glu-TTC-1 were significantly upregulated in HG-treated tubular epithelial cells (Fig. 2B-E). tRF-1:30-Gln-CTG-4, tRF-1:28-Gly-CCC-1, tRF-1:29-Val-AAC-5 and tRF-1:30-Val-AAC-5 were significantly downregulated (Fig. 2F, ​,G,G, ​,II and ​andJ).J).
Comparision:HG VS Normal
Mechanism:N/A