Entry Detail



General Information

Database ID:TRD02620
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF_U3_1
tsRNA Type:tRF-3
Amino acid and Anticodon:SerTGA
Sequence:N/A
Related Target:N/A
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:2
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D006528DOID:684
Disease Name:Carcinoma, Hepatocellularhepatocellular carcinoma
Category:MeSHDisease Ontology
Type:Neoplasms//Digestive System Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.
Alias:Hepatocellular Carcinoma//Hepatoma//Liver Cancer, Adult//Liver Cell Carcinoma//Liver Cell Carcinoma, AdultHepatoma



Disease Association Statistics

Total Associated tsRNA Number:61
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:31504775
Disease Name:Carcinoma, Hepatocellular
Tissue:Hepatocellular Carcinoma Cell Line
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:Overall, our results establish the trailer-La/SSB interface, which regulates viral gene expression, and demonstrate a critical role of La/SSB in stabilization of the trailer released from pretRNA in the cytoplasm.
Comparision:Cancer VS Normal
Mechanism:We show that the trailer-derived tRFs negatively regulate La/SSB-dependent viral gene expression by sequestering the RNA chaperone La/SSB.