Entry Detail



General Information

Database ID:TRD02494
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:ProTGG 3′-tRF
tsRNA Type:tRF-3
Amino acid and Anticodon:ProTGG
Sequence:N/A
Related Target:CPEB3
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:1
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D006258DOID:11934
Disease Name:Head and Neck NeoplasmsHead and neck cancer
Category:MeSHDisease Ontology
Type:Neoplasmsdisease of cellular proliferation
Define:Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx.
Alias://Cancer of Head//Cancer of Head and Neck//Cancer of Neck//Cancer of the Head//Cancer of the Head and Neck//Cancer of the Neck//Head Cancer//Head Neoplasm//Head Neoplasms//Head and Neck Cancer//Head and Neck Neoplasm//Head, Neck Neoplasms//Neck Cancer//Neck Neoplasm//Neck Neoplasms//Neoplasms, Head//Neoplasms, Head and Neck//Neoplasms Neck//Neoplasms, Upper Aerodigestive Tract//UADT Neoplasm//UADT Neoplasms//Upper Aerodigestive Tract Neoplasm//Upper Aerodigestive Tract Neoplasmshead and neck neoplasm//head and neck tumours//head/neck neoplasm//tumor of head and neck



Disease Association Statistics

Total Associated tsRNA Number:3
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:39317063
Disease Name:Head and Neck Neoplasms
Tissue:Oral Cavity
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:Among others, CysGCA 5′-half and LysCTT 3′-tRF were upregulated in the tumor samples, and corresponded to decreased expression of PIK3R1, AKT1, and CPEB5. These transcripts were further found to contain numerous significantly complementary sites at which tRF-mediated mRNA degradation might occur. Although these tRFs did appear to correlate to many of the oncogenic metrics analyzed, we believe that additional research is needed before they might be used to improve the diagnosis, treatment, and survival of patients with this disease.
Comparision:Cancer VS Normal
Mechanism:N/A