Entry Detail


General Information

Database ID:TRD02390
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-56:73-chrM.Lys-TTT
tsRNA Type:tRF-3
Amino acid and Anticodon:LysTTT
Sequence:N/A
Related Target:N/A
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:2
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D015179DOID:9256
Disease Name:Colorectal Neoplasmscolorectal cancer
Category:MeSHDisease Ontology
Type:Neoplasms//Digestive System Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.A large intestine cancer that is located_in the colon and/or located_in the rectum.
Alias:Colorectal Cancer//Colorectal Carcinoma//Colorectal Tumors//Neoplasms, ColorectalN/A



Disease Association Statistics

Total Associated tsRNA Number:195
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:37864471
Disease Name:Colorectal Neoplasms
Tissue:Colon
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:The expression of these tsRNAs in SW620/R and HCT116/R cells was validated by qRT‐PCR (Figure 3), which revealed that tRF‐30.43‐Gln‐CTG‐1‐M6 and tRF‐1.30‐Glu‐TTC‐3‐M2 were substantially upregulated in both radiation‐resistant cell lines, while tiRNA‐1.33‐Pro‐TGG‐3 and tRF‐1.16‐chrM.Phe‐GAA was markedly downregulated, consistent with the sequencing results.
Comparision:Radiation‐Resistant VS Wild‐Type Cells
Mechanism:N/A