Entry Detail


General Information

Database ID:TRD02303
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-3001a
tsRNA Type:tRF-3
Amino acid and Anticodon:LeuAAG;LeuTAG
Sequence:ATCCCACCGCTGCCACCA
Related Target:GSK3B
Predicted Target:ZNF853//KIF3B//MAML2//APOBR//VAX2//PHF19//POU3F3//RAN//ANKIB1//NGB
External Links:
MINTbase ID:tRF-18-HR0VX6D2
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Leu-AAG-4-1
Anticodon:LeuAAG
tRNA_number:trna126
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 28446400-3        End Site(bp): 28446414

[2] gtRNAdb_ID:tRNA-Leu-AAG-3-1
Anticodon:LeuAAG
tRNA_number:trna78
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 28956846        End Site(bp): 28956860+3

[3] gtRNAdb_ID:tRNA-Leu-AAG-2-3
Anticodon:LeuAAG
tRNA_number:trna1
Chromosome:14
Strand:+
Coordinate:Start Site(bp): 21078358        End Site(bp): 21078372+3

[4] gtRNAdb_ID:tRNA-Leu-AAG-2-4
Anticodon:LeuAAG
tRNA_number:trna16
Chromosome:16
Strand:+
Coordinate:Start Site(bp): 22308528        End Site(bp): 22308542+3

[5] gtRNAdb_ID:tRNA-Leu-AAG-2-1
Anticodon:LeuAAG
tRNA_number:trna7
Chromosome:5
Strand:+
Coordinate:Start Site(bp): 180614768        End Site(bp): 180614782+3

[6] gtRNAdb_ID:tRNA-Leu-AAG-2-2
Anticodon:LeuAAG
tRNA_number:trna98
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 28911399-3        End Site(bp): 28911413

[7] gtRNAdb_ID:tRNA-Leu-AAG-1-3
Anticodon:LeuAAG
tRNA_number:trna16
Chromosome:5
Strand:-
Coordinate:Start Site(bp): 180601044-3        End Site(bp): 180601058

[8] gtRNAdb_ID:tRNA-Leu-AAG-1-1
Anticodon:LeuAAG
tRNA_number:trna19
Chromosome:5
Strand:-
Coordinate:Start Site(bp): 180524474-3        End Site(bp): 180524488

[9] gtRNAdb_ID:tRNA-Leu-AAG-1-2
Anticodon:LeuAAG
tRNA_number:trna3
Chromosome:5
Strand:+
Coordinate:Start Site(bp): 180528907        End Site(bp): 180528921+3

[10] gtRNAdb_ID:tRNA-Leu-TAG-3-1
Anticodon:LeuTAG
tRNA_number:trna27
Chromosome:16
Strand:-
Coordinate:Start Site(bp): 22207032-3        End Site(bp): 22207046

[11] gtRNAdb_ID:tRNA-Leu-TAG-1-1
Anticodon:LeuTAG
tRNA_number:trna42
Chromosome:17
Strand:-
Coordinate:Start Site(bp): 8023632-3        End Site(bp): 8023646



tsRNA Association Statistics

Total Associated Disease Number:6
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D003930DOID:13207
Disease Name:Diabetic Retinopathyproliferative diabetic retinopathy
Category:MeSHDisease Ontology
Type:Eye Diseases//Cardiovascular Diseases//Endocrine System Diseasesdisease of anatomical entity//nervous system disease
Define:Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.N/A
Alias:N/APDR



Disease Association Statistics

Total Associated tsRNA Number:86
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR//Western blot
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:37757825
Disease Name:Diabetic Retinopathy
Tissue:Retina
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//Western blot//High-throughput sequencing
Description:Targeting tRF-3001a-mediated signaling is a promising strategy for the concurrent treatment of vasculopathy and neuropathy in diabetes mellitus
Comparision:Disease VS Control
Mechanism:TRF-3001a regulates neurovascular dysfunction in a microRNA-like mechanism by targeting GSK3B