Entry Detail


General Information

Database ID:TRD02288
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF3-IleAAT
tsRNA Type:tRF-3
Amino acid and Anticodon:IleAAT
Sequence:TCGATCCCCGTACGGGCCACCA
Related Target:N/A
Predicted Target:HCLS1//ABI3//SAMD4B//HNRNPUL2//HNRNPUL2-BSCL2//ACSM3//TRMT44//COL9A3//PKD2L2//GIMAP1
External Links:
MINTbase ID:tRF-22-WEKSU8P52
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Ile-AAT-8-1
Anticodon:IleAAT
tRNA_number:trna57
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 27636417        End Site(bp): 27636435+3

[2] gtRNAdb_ID:tRNA-Ile-AAT-7-1
Anticodon:IleAAT
tRNA_number:trna165
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 26721221-3        End Site(bp): 26721239

[3] gtRNAdb_ID:tRNA-Ile-AAT-7-2
Anticodon:IleAAT
tRNA_number:trna28
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 26780887        End Site(bp): 26780905+3

[4] gtRNAdb_ID:tRNA-Ile-AAT-5-4
Anticodon:IleAAT
tRNA_number:trna10
Chromosome:14
Strand:+
Coordinate:Start Site(bp): 102783484        End Site(bp): 102783502+3

[5] gtRNAdb_ID:tRNA-Ile-AAT-5-5
Anticodon:IleAAT
tRNA_number:trna9
Chromosome:17
Strand:+
Coordinate:Start Site(bp): 8090966        End Site(bp): 8090984+3

[6] gtRNAdb_ID:tRNA-Ile-AAT-5-1
Anticodon:IleAAT
tRNA_number:trna11
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 26554405        End Site(bp): 26554423+3

[7] gtRNAdb_ID:tRNA-Ile-AAT-5-3
Anticodon:IleAAT
tRNA_number:trna154
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 27205350-3        End Site(bp): 27205368

[8] gtRNAdb_ID:tRNA-Ile-AAT-5-2
Anticodon:IleAAT
tRNA_number:trna158
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 27144994-3        End Site(bp): 27145012

[9] gtRNAdb_ID:tRNA-Ile-AAT-1-1
Anticodon:IleAAT
tRNA_number:trna80
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 58149309        End Site(bp): 58149327+3



tsRNA Association Statistics

Total Associated Disease Number:2
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D003928N/A
Disease Name:Diabetic NephropathiesN/A
Category:MeSHDisease Ontology
Type:Urogenital Diseases//Endocrine System DiseasesN/A
Define:KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.N/A
Alias:Diabetic Glomerulosclerosis//Diabetic Kidney Disease//Diabetic Nephropathy//Glomerulosclerosis, Diabetic//Intracapillary//Glomerulosclerosis//Kimmelstiel-Wilson Disease//Kimmelstiel-Wilson Syndrome//Nodular GlomerulosclerosisN/A



Disease Association Statistics

Total Associated tsRNA Number:29
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:37273759
Disease Name:Diabetic Nephropathies
Tissue:Serum samples
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:Ultimately, six differentially expressed (DE) tRFs were identified (P<0.05; |log2fold change| ≥1), including three upregulated (tRF5-GluCTC, tRF5-AlaCGC and tRF5-ValCAC) and three downregulated tRFs (tRF5-GlyCCC, tRF3-GlyGCC and tRF3-IleAAT).
Comparision:DN VS Diabetes Mellitus
Mechanism:In conclusion, GO analysis suggested that the DE tRFs may be associated with DN pathology.