Entry Detail


General Information

Database ID:TRD02280
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:i-tRFle-AAT-019
tsRNA Type:tRF-3
Amino acid and Anticodon:IleAAT
Sequence:TCCCCGTACGGGCCACCA
Related Target:SERPINE1
Predicted Target:RNF39//HCLS1//LPCAT3//COL9A3//PRRC2B//NUTM2D//ALKAL2//DOK2//HLA-C//DNAH1
External Links:
MINTbase ID:tRF-18-8RSH66D2
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Ile-AAT-8-1
Anticodon:IleAAT
tRNA_number:trna57
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 27636421        End Site(bp): 27636435+3

[2] gtRNAdb_ID:tRNA-Ile-AAT-7-1
Anticodon:IleAAT
tRNA_number:trna165
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 26721221-3        End Site(bp): 26721235

[3] gtRNAdb_ID:tRNA-Ile-AAT-7-2
Anticodon:IleAAT
tRNA_number:trna28
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 26780891        End Site(bp): 26780905+3

[4] gtRNAdb_ID:tRNA-Ile-AAT-5-4
Anticodon:IleAAT
tRNA_number:trna10
Chromosome:14
Strand:+
Coordinate:Start Site(bp): 102783488        End Site(bp): 102783502+3

[5] gtRNAdb_ID:tRNA-Ile-AAT-5-5
Anticodon:IleAAT
tRNA_number:trna9
Chromosome:17
Strand:+
Coordinate:Start Site(bp): 8090970        End Site(bp): 8090984+3

[6] gtRNAdb_ID:tRNA-Ile-AAT-5-1
Anticodon:IleAAT
tRNA_number:trna11
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 26554409        End Site(bp): 26554423+3

[7] gtRNAdb_ID:tRNA-Ile-AAT-5-3
Anticodon:IleAAT
tRNA_number:trna154
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 27205350-3        End Site(bp): 27205364

[8] gtRNAdb_ID:tRNA-Ile-AAT-5-2
Anticodon:IleAAT
tRNA_number:trna158
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 27144994-3        End Site(bp): 27145008

[9] gtRNAdb_ID:tRNA-Ile-AAT-1-1
Anticodon:IleAAT
tRNA_number:trna80
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 58149313        End Site(bp): 58149327+3



tsRNA Association Statistics

Total Associated Disease Number:21
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D011565DOID:8893
Disease Name:Psoriasispsoriasis
Category:MeSHDisease Ontology
Type:Skin and Connective Tissue Diseasesdisease of anatomical entity
Define:A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.A skin disease that is characterized by patches of thick red skin and silvery scales.
Alias:Palmoplantaris Pustulosis//Pustular Psoriasis of Palms and Soles//Pustulosis Palmaris et Plantaris//Pustulosis of Palms and SolesN/A



Disease Association Statistics

Total Associated tsRNA Number:71
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:36251463
Disease Name:Psoriasis
Tissue:Psoriatic Skin Lesions
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:i-tRFle-AAT-019 plays a protective role in the pathological progression of psoriasis via targeting SERPINE1, resulting in regulation of KCs differentiation and vascular proliferation biomarkers and providing a potential novel targeting pathway for the disease treatment.
Comparision:Disease VS Control
Mechanism:i-tRFle-AAT-019 could suppress SERPINE1, thus leading to decreased expressions of vascular endothelial growth factor but increased expressions of keratinocytes (KCs) differentiation markers including Keratin1 and Involucrin.