Entry Detail


General Information

Database ID:TRD02218
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF3-GlyGCC
tsRNA Type:tRF-3
Amino acid and Anticodon:GlyGCC
Sequence:TCGATTCCCGGCCCATGCACCA
Related Target:N/A
Predicted Target:DDX51//FCGR2A//CYP2W1//NAP1L4//ANXA2//AHDC1//PRSS36//MLST8//CACNA1E//SPPL2B
External Links:
MINTbase ID:tRF-22-WE8SP6X52
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Gly-GCC-1-1
Anticodon:GlyGCC
tRNA_number:trna35
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161413146        End Site(bp): 161413164+3

[2] gtRNAdb_ID:tRNA-Gly-GCC-1-2
Anticodon:GlyGCC
tRNA_number:trna37
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161420519        End Site(bp): 161420537+3

[3] gtRNAdb_ID:tRNA-Gly-GCC-1-3
Anticodon:GlyGCC
tRNA_number:trna39
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161427950        End Site(bp): 161427968+3

[4] gtRNAdb_ID:tRNA-Gly-GCC-1-4
Anticodon:GlyGCC
tRNA_number:trna41
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161435310        End Site(bp): 161435328+3

[5] gtRNAdb_ID:tRNA-Gly-GCC-1-5
Anticodon:GlyGCC
tRNA_number:trna2
Chromosome:21
Strand:-
Coordinate:Start Site(bp): 18827107-3        End Site(bp): 18827125



tsRNA Association Statistics

Total Associated Disease Number:2
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D003928N/A
Disease Name:Diabetic NephropathiesN/A
Category:MeSHDisease Ontology
Type:Urogenital Diseases//Endocrine System DiseasesN/A
Define:KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.N/A
Alias:Diabetic Glomerulosclerosis//Diabetic Kidney Disease//Diabetic Nephropathy//Glomerulosclerosis, Diabetic//Intracapillary//Glomerulosclerosis//Kimmelstiel-Wilson Disease//Kimmelstiel-Wilson Syndrome//Nodular GlomerulosclerosisN/A



Disease Association Statistics

Total Associated tsRNA Number:29
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:37273759
Disease Name:Diabetic Nephropathies
Tissue:Serum samples
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:Ultimately, six differentially expressed (DE) tRFs were identified (P<0.05; |log2fold change| ≥1), including three upregulated (tRF5-GluCTC, tRF5-AlaCGC and tRF5-ValCAC) and three downregulated tRFs (tRF5-GlyCCC, tRF3-GlyGCC and tRF3-IleAAT).
Comparision:DN VS Diabetes Mellitus
Mechanism:In conclusion, GO analysis suggested that the DE tRFs may be associated with DN pathology.