Entry Detail


General Information

Database ID:TRD02214
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-22-WE8SPOX52
tsRNA Type:tRF-3
Amino acid and Anticodon:GlyGCC
Sequence:TCGATTCCCGGCCAATGCACCA
Related Target:N/A
Predicted Target:FCGR2A//MAVS//DDX51//PNPT1//PRSS36//DPM1//CACNA1E//ANKAR//PPP1R15A//ADH6
External Links:
MINTbase ID:tRF-22-WE8SPOX52
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Gly-GCC-2-1
Anticodon:GlyGCC
tRNA_number:trna68
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161493637-3        End Site(bp): 161493655

[2] gtRNAdb_ID:tRNA-Gly-GCC-2-5
Anticodon:GlyGCC
tRNA_number:trna19
Chromosome:16
Strand:+
Coordinate:Start Site(bp): 70823462        End Site(bp): 70823480+3

[3] gtRNAdb_ID:tRNA-Gly-GCC-2-4
Anticodon:GlyGCC
tRNA_number:trna24
Chromosome:16
Strand:-
Coordinate:Start Site(bp): 70812942-3        End Site(bp): 70812960

[4] gtRNAdb_ID:tRNA-Gly-GCC-2-6
Anticodon:GlyGCC
tRNA_number:trna5
Chromosome:17
Strand:+
Coordinate:Start Site(bp): 8029116        End Site(bp): 8029134+3

[5] gtRNAdb_ID:tRNA-Gly-GCC-2-2
Anticodon:GlyGCC
tRNA_number:trna19
Chromosome:2
Strand:-
Coordinate:Start Site(bp): 157257659-3        End Site(bp): 157257677

[6] gtRNAdb_ID:tRNA-Gly-GCC-2-3
Anticodon:GlyGCC
tRNA_number:trna128
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 27870686-3        End Site(bp): 27870704



tsRNA Association Statistics

Total Associated Disease Number:7
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D020521N/A
Disease Name:StrokeN/A
Category:MeSHDisease Ontology
Type:Nervous System Diseases//Cardiovascular DiseasesN/A
Define:A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)N/A
Alias:Apoplexy//CVA (Cerebrovascular Accident)//Cerebral Stroke//Cerebrovascular Accident//Cerebrovascular Accident, Acute//Cerebrovascular Apoplexy//Cerebrovascular Stroke//Stroke, Acute//Vascular Accident, BrainN/A



Disease Association Statistics

Total Associated tsRNA Number:46
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:33288717
Disease Name:Stroke
Tissue:N/A
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:N/A
Comparision:LPS Stimulation VS NC
Mechanism:By 18 h after LPS stimulation,qRT-PCR analysis after size-selection (for <=53-nt fragments) detected pronounced Up-Regulation of the top six poststroke up-regulated tRFs.

[2] PubMed ID:33288717
Disease Name:Stroke
Tissue:N/A
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:N/A
Comparision:Overexpressed tRF VS NC
Mechanism:We overexpressed this tRF using single-stranded RNA (ssRNA) mimics (Fig. 6D and SI Appendix,Fig. S7), which significantly reduced the expression of its Zbp1 target compared to negative control.