Entry Detail


General Information

Database ID:TRD02211
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:CU1276
tsRNA Type:tRF-3
Amino acid and Anticodon:GlyGCC
Sequence:TCGATTCCCGGCCAATGCACCA
Related Target:N/A
Predicted Target:FCGR2A//MAVS//DDX51//PNPT1//PRSS36//DPM1//CACNA1E//ANKAR//PPP1R15A//ADH6
External Links:
MINTbase ID:tRF-22-WE8SPOX52
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Gly-GCC-2-1
Anticodon:GlyGCC
tRNA_number:trna68
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161493637-3        End Site(bp): 161493655

[2] gtRNAdb_ID:tRNA-Gly-GCC-2-5
Anticodon:GlyGCC
tRNA_number:trna19
Chromosome:16
Strand:+
Coordinate:Start Site(bp): 70823462        End Site(bp): 70823480+3

[3] gtRNAdb_ID:tRNA-Gly-GCC-2-4
Anticodon:GlyGCC
tRNA_number:trna24
Chromosome:16
Strand:-
Coordinate:Start Site(bp): 70812942-3        End Site(bp): 70812960

[4] gtRNAdb_ID:tRNA-Gly-GCC-2-6
Anticodon:GlyGCC
tRNA_number:trna5
Chromosome:17
Strand:+
Coordinate:Start Site(bp): 8029116        End Site(bp): 8029134+3

[5] gtRNAdb_ID:tRNA-Gly-GCC-2-2
Anticodon:GlyGCC
tRNA_number:trna19
Chromosome:2
Strand:-
Coordinate:Start Site(bp): 157257659-3        End Site(bp): 157257677

[6] gtRNAdb_ID:tRNA-Gly-GCC-2-3
Anticodon:GlyGCC
tRNA_number:trna128
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 27870686-3        End Site(bp): 27870704



tsRNA Association Statistics

Total Associated Disease Number:1
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D016393DOID:707
Disease Name:Lymphoma, B-CellB-cell lymphoma
Category:MeSHDisease Ontology
Type:Neoplasms//Hemic and Lymphatic Diseases//Immune System Diseasesdisease of cellular proliferation//disease of anatomical entity
Define:A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.A non-Hodgkin lymphoma that has_material_basis_in B cells.
Alias:B-Cell LymphomaB-cell lymphocytic neoplasm



Disease Association Statistics

Total Associated tsRNA Number:17
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:Transfection//Northern blot
Weak Evidence:N/A



Reference

[1] PubMed ID:23297232
Disease Name:Lymphoma, B-Cell
Tissue:Lymph
Dysfunction Pattern:Down-Regulation
Validated Method:Transfection//Northern blot
Description:CU1276 is down-regulated in lymphoma cell lines and primary biopsies.
Comparision:Cancer VS Normal
Mechanism:tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma.