Entry Detail


General Information

Database ID:TRD02077
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-56:75-Gln-CTG-2
tsRNA Type:tRF-3
Amino acid and Anticodon:GlnCTG
Sequence:N/A
Related Target:N/A
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:5
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D003930DOID:13207
Disease Name:Diabetic Retinopathyproliferative diabetic retinopathy
Category:MeSHDisease Ontology
Type:Eye Diseases//Cardiovascular Diseases//Endocrine System Diseasesdisease of anatomical entity//nervous system disease
Define:Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.N/A
Alias:N/APDR



Disease Association Statistics

Total Associated tsRNA Number:86
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:35903272
Disease Name:Diabetic Retinopathy
Tissue:Vitreous humor samples
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:The top 10 up- and down-regulated tsRNAs are listed in Table 4.
Comparision:PDR VS Normal
Mechanism:In this study, we identified the AMPK signaling pathway as a leading enriched pathway associated with the altered tsRNAs (Figure 4B), which also suggested that these tsRNAs might have regulatory functions in the pathogenesis of DR.