Entry Detail


General Information

Database ID:TRD02065
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRFdb-3003a
tsRNA Type:tRF-3
Amino acid and Anticodon:CysGCA
Sequence:TCCGGGTGCCCCCTCCA
Related Target:N/A
Predicted Target:VSX2//MAN1A1//PDGFC//POLR2H//FAM181B//JAKMIP1//C4orf50//PDZRN3//TSPY2//CLIC6
External Links:
MINTbase ID:N/A
tRFdb ID:tRFdb-3003a

[1] gtRNAdb_ID:tRNA-Cys-GCA-14-1
Anticodon:CysGCA
tRNA_number:trna29
Chromosome:17
Strand:-
Coordinate:Start Site(bp): 37017937-3        End Site(bp): 37017950

[2] gtRNAdb_ID:tRNA-Cys-GCA-11-1
Anticodon:CysGCA
tRNA_number:trna21
Chromosome:7
Strand:-
Coordinate:Start Site(bp): 149112229-3        End Site(bp): 149112242

[3] gtRNAdb_ID:tRNA-Cys-GCA-8-1
Anticodon:CysGCA
tRNA_number:trna8
Chromosome:14
Strand:+
Coordinate:Start Site(bp): 73429737        End Site(bp): 73429750+3

[4] gtRNAdb_ID:tRNA-Cys-GCA-7-1
Anticodon:CysGCA
tRNA_number:trna127
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 93981834-3        End Site(bp): 93981847

[5] gtRNAdb_ID:tRNA-Cys-GCA-5-1
Anticodon:CysGCA
tRNA_number:trna3
Chromosome:15
Strand:+
Coordinate:Start Site(bp): 80037056        End Site(bp): 80037069+3

[6] gtRNAdb_ID:tRNA-Cys-GCA-4-1
Anticodon:CysGCA
tRNA_number:trna28
Chromosome:17
Strand:-
Coordinate:Start Site(bp): 37025545-3        End Site(bp): 37025558

[7] gtRNAdb_ID:tRNA-Cys-GCA-2-2
Anticodon:CysGCA
tRNA_number:trna15
Chromosome:17
Strand:+
Coordinate:Start Site(bp): 37023956        End Site(bp): 37023969+3

[8] gtRNAdb_ID:tRNA-Cys-GCA-2-4
Anticodon:CysGCA
tRNA_number:trna26
Chromosome:17
Strand:-
Coordinate:Start Site(bp): 37310744-3        End Site(bp): 37310757

[9] gtRNAdb_ID:tRNA-Cys-GCA-2-3
Anticodon:CysGCA
tRNA_number:trna27
Chromosome:17
Strand:-
Coordinate:Start Site(bp): 37309987-3        End Site(bp): 37310000

[10] gtRNAdb_ID:tRNA-Cys-GCA-2-1
Anticodon:CysGCA
tRNA_number:trna3
Chromosome:4
Strand:-
Coordinate:Start Site(bp): 124430005-3        End Site(bp): 124430018



tsRNA Association Statistics

Total Associated Disease Number:2
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D005910DOID:0060108
Disease Name:Gliomabrain glioma
Category:MeSHDisease Ontology
Type:Neoplasmsdisease of cellular proliferation//disease of anatomical entity
Define:Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)A brain cancer that has_material_basis_in glial cells.
Alias:Glial Cell Tumors//Malignant Glioma//Mixed Gliomalower grade glioma



Disease Association Statistics

Total Associated tsRNA Number:29
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:PCR//Western blot
Weak Evidence:Data Mining



Reference

[1] PubMed ID:36426134
Disease Name:Glioma
Tissue:Brain
Dysfunction Pattern:Down-Regulation
Validated Method:PCR//Western blot//Data Mining
Description:Among tsRNAs derived from tRNA-Cys-GCA, tRFdb-3003a and tRFdb-3003b (tRFdb-3003a/b) were remarkably down-regulated in gliomas.
Comparision:Cancer VS Normal
Mechanism:The tRNA-Cys-GCA derived tRFdb-3003a and tRFdb-3003b might act as key player in tumor progressions of gliomas; tRFdb-3003a/b might directly bind to VAV2 and regulate VAV2 expressions in gliomas.