Entry Detail


General Information

Database ID:TRD02058
Confidence:Median
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-Cys-GCA-004
tsRNA Type:tRF-3
Amino acid and Anticodon:CysGCA
Sequence:TCCGGGTGCCCCCTCCA
Related Target:N/A
Predicted Target:VSX2//MAN1A1//PDGFC//POLR2H//FAM181B//JAKMIP1//C4orf50//PDZRN3//TSPY2//CLIC6
External Links:
MINTbase ID:tRF-17-8871K92
tRFdb ID:tRFdb-3003a

[1] gtRNAdb_ID:tRNA-Cys-GCA-14-1
Anticodon:CysGCA
tRNA_number:trna29
Chromosome:17
Strand:-
Coordinate:Start Site(bp): 37017937-3        End Site(bp): 37017950

[2] gtRNAdb_ID:tRNA-Cys-GCA-11-1
Anticodon:CysGCA
tRNA_number:trna21
Chromosome:7
Strand:-
Coordinate:Start Site(bp): 149112229-3        End Site(bp): 149112242

[3] gtRNAdb_ID:tRNA-Cys-GCA-8-1
Anticodon:CysGCA
tRNA_number:trna8
Chromosome:14
Strand:+
Coordinate:Start Site(bp): 73429737        End Site(bp): 73429750+3

[4] gtRNAdb_ID:tRNA-Cys-GCA-7-1
Anticodon:CysGCA
tRNA_number:trna127
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 93981834-3        End Site(bp): 93981847

[5] gtRNAdb_ID:tRNA-Cys-GCA-5-1
Anticodon:CysGCA
tRNA_number:trna3
Chromosome:15
Strand:+
Coordinate:Start Site(bp): 80037056        End Site(bp): 80037069+3

[6] gtRNAdb_ID:tRNA-Cys-GCA-4-1
Anticodon:CysGCA
tRNA_number:trna28
Chromosome:17
Strand:-
Coordinate:Start Site(bp): 37025545-3        End Site(bp): 37025558

[7] gtRNAdb_ID:tRNA-Cys-GCA-2-2
Anticodon:CysGCA
tRNA_number:trna15
Chromosome:17
Strand:+
Coordinate:Start Site(bp): 37023956        End Site(bp): 37023969+3

[8] gtRNAdb_ID:tRNA-Cys-GCA-2-4
Anticodon:CysGCA
tRNA_number:trna26
Chromosome:17
Strand:-
Coordinate:Start Site(bp): 37310744-3        End Site(bp): 37310757

[9] gtRNAdb_ID:tRNA-Cys-GCA-2-3
Anticodon:CysGCA
tRNA_number:trna27
Chromosome:17
Strand:-
Coordinate:Start Site(bp): 37309987-3        End Site(bp): 37310000

[10] gtRNAdb_ID:tRNA-Cys-GCA-2-1
Anticodon:CysGCA
tRNA_number:trna3
Chromosome:4
Strand:-
Coordinate:Start Site(bp): 124430005-3        End Site(bp): 124430018



tsRNA Association Statistics

Total Associated Disease Number:7
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D009914DOID:5773
Disease Name:Oral Submucous Fibrosisoral submucous fibrosis
Category:MeSHDisease Ontology
Type:Stomatognathic Diseasesdisease of anatomical entity
Define:Irreversible FIBROSIS of the submucosal tissue of the MOUTH.A mouth disease that is characterized by juxta-epithelial inflammatory reaction and progressive fibrosis of the submucosal tissues.
Alias:N/AOral cavity Submucous Fibrosis//Oral submucosal fibrosis//Oral submucosal fibrosis, including of tongue



Disease Association Statistics

Total Associated tsRNA Number:126
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:N/A
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:34558114
Disease Name:Oral Submucous Fibrosis
Tissue:Oral Submucous Fibrosis
Dysfunction Pattern:Down-Regulation
Validated Method:High-throughput sequencing
Description:Of 126 tsRNAs in OSF were dysregulated, including 73 upregulated tsRNAs and 53 downregulated tsRNAs. The downregulated tiRNA-Val-CAC-002,tRF-Asn-GTT-005, tRF-Trp-CCA-007 and upregulated tRF-Gly-TCC-016,tRF-Pro-TGG-009 showed significant differences by qRT-PCR validation.
Comparision:Disease VS Control
Mechanism:tRNA-derived fragments are dysregulated and could be involved in the pathogenesis of oral submucous fibrosis.