Entry Detail


General Information

Database ID:TRD02032
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-3024b
tsRNA Type:tRF-3
Amino acid and Anticodon:AspGTC
Sequence:TCGATTCCCCGACGGGGAGCCA
Related Target:Bcl2
Predicted Target:NDUFA8//FIGNL2//MAOA//XKR4//CDC14B//ELOF1//ACTR2//RSBN1//C5orf63//CHRNA4
External Links:
MINTbase ID:tRF-22-WE8RO86J2
tRFdb ID:tRFdb-3024b

[1] gtRNAdb_ID:tRNA-Asp-GTC-10-1
Anticodon:AspGTC
tRNA_number:trna44
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161492988        End Site(bp): 161493006+3

[2] gtRNAdb_ID:tRNA-Asp-GTC-3-1
Anticodon:AspGTC
tRNA_number:trna144
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 27551236-3        End Site(bp): 27551254

[3] gtRNAdb_ID:tRNA-Asp-GTC-2-5
Anticodon:AspGTC
tRNA_number:trna69
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161440205-3        End Site(bp): 161440223

[4] gtRNAdb_ID:tRNA-Asp-GTC-2-4
Anticodon:AspGTC
tRNA_number:trna72
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161432824-3        End Site(bp): 161432842

[5] gtRNAdb_ID:tRNA-Asp-GTC-2-3
Anticodon:AspGTC
tRNA_number:trna75
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161425414-3        End Site(bp): 161425432

[6] gtRNAdb_ID:tRNA-Asp-GTC-2-2
Anticodon:AspGTC
tRNA_number:trna78
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161418033-3        End Site(bp): 161418051

[7] gtRNAdb_ID:tRNA-Asp-GTC-2-1
Anticodon:AspGTC
tRNA_number:trna81
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161410615-3        End Site(bp): 161410633

[8] gtRNAdb_ID:tRNA-Asp-GTC-2-10
Anticodon:AspGTC
tRNA_number:trna10
Chromosome:12
Strand:-
Coordinate:Start Site(bp): 125424193-3        End Site(bp): 125424211

[9] gtRNAdb_ID:tRNA-Asp-GTC-2-9
Anticodon:AspGTC
tRNA_number:trna12
Chromosome:12
Strand:-
Coordinate:Start Site(bp): 125411891-3        End Site(bp): 125411909

[10] gtRNAdb_ID:tRNA-Asp-GTC-2-8
Anticodon:AspGTC
tRNA_number:trna4
Chromosome:12
Strand:+
Coordinate:Start Site(bp): 96429852        End Site(bp): 96429870+3

[11] gtRNAdb_ID:tRNA-Asp-GTC-2-11
Anticodon:AspGTC
tRNA_number:trna38
Chromosome:17
Strand:-
Coordinate:Start Site(bp): 8125556-3        End Site(bp): 8125574

[12] gtRNAdb_ID:tRNA-Asp-GTC-2-6
Anticodon:AspGTC
tRNA_number:trna45
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 27447506        End Site(bp): 27447524+3

[13] gtRNAdb_ID:tRNA-Asp-GTC-2-7
Anticodon:AspGTC
tRNA_number:trna48
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 27471576        End Site(bp): 27471594+3



tsRNA Association Statistics

Total Associated Disease Number:1
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D000077277DOID:3748
Disease Name:Esophageal Squamous Cell Carcinomaesophagus squamous cell carcinoma
Category:MeSHDisease Ontology
Type:Neoplasms//Digestive System Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:A carcinoma that originates usually from cells on the surface of the middle and lower third of the ESOPHAGUS. Tumor cells exhibit typical squamous morphology and form large polypoid lesions. Mutations in RNF6, LZTS1, TGFBR2, DEC1, and WWOX1 genes are associated with this cancer.An esophageal carcinoma that derives_from epithelial squamous cells located_in the esophagus.
Alias:Oesophageal Squamous Cell Carcinomaoesophagus squamous cell carcinoma//SCC of esophagus//SCC of oesophagus



Disease Association Statistics

Total Associated tsRNA Number:32
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:37977065
Disease Name:Esophageal Squamous Cell Carcinoma
Tissue:Cell
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:The tRF-3024b hijacks miR-192-5p to increase BCL-2-mediated resistance to cytotoxic T lymphocytes in Esophageal Squamous Cell Carcinoma.
Comparision:Cancer VS Normal
Mechanism:We observed a high expression of tRF-3024b in ESCC cells that survived co-culture with CTLs. Further in vitro studies demonstrated that tRF-3024b reduced the apoptosis of tumor cells when co-cultured with CTLs. The mechanism behind this resistance involves tRF-3024b promoting the expression of B-cell lymphoma-2 (BCL-2) by sequestering miR-192-5p, a microRNA that would normally inhibit BCL-2 expression. This means that tRF-3024b indirectly enhances the protective effects of BCL-2, reducing apoptosis in tumor cells. Rescue assays confirmed that the suppressive function of tRF-3024b relies on BCL-2. In summary, the tRF-3024b/ miR-192-5p/BCL-2 axis sheds light on the crucial role of tRF-3024b in regulating BCL-2 expression. These findings offer valuable insights into strategies to enhance the response of ESCC to CTLs and improve the effectiveness of immunotherapy approaches in treating ESCC.