Entry Detail


General Information

Database ID:TRD01928
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-16-K8J7K1B
tsRNA Type:tRF-3
Amino acid and Anticodon:AlaCGC;AlaTGC
Sequence:CCCGGCATCTCCACCA
Related Target:TRAIL
Predicted Target:PLXNB1//MEGF8//SEC14L1//PAPLN//GPRIN1//WTIP//RETREG3//C5AR2//RAB43//ISY1-RAB43
External Links:
MINTbase ID:tRF-16-K8J7K1B
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Ala-CGC-3-1
Anticodon:AlaCGC
tRNA_number:trna13
Chromosome:2
Strand:+
Coordinate:Start Site(bp): 157257340        End Site(bp): 157257352+3

[2] gtRNAdb_ID:tRNA-Ala-CGC-2-1
Anticodon:AlaCGC
tRNA_number:trna119
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 28641613-3        End Site(bp): 28641625

[3] gtRNAdb_ID:tRNA-Ala-CGC-1-1
Anticodon:AlaCGC
tRNA_number:trna10
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 26553790        End Site(bp): 26553802+3

[4] gtRNAdb_ID:tRNA-Ala-TGC-4-1
Anticodon:AlaTGC
tRNA_number:trna8
Chromosome:12
Strand:+
Coordinate:Start Site(bp): 125424571        End Site(bp): 125424583+3

[5] gtRNAdb_ID:tRNA-Ala-TGC-3-2
Anticodon:AlaTGC
tRNA_number:trna13
Chromosome:12
Strand:-
Coordinate:Start Site(bp): 125406301-3        End Site(bp): 125406313

[6] gtRNAdb_ID:tRNA-Ala-TGC-3-1
Anticodon:AlaTGC
tRNA_number:trna8
Chromosome:5
Strand:+
Coordinate:Start Site(bp): 180633927        End Site(bp): 180633939+3

[7] gtRNAdb_ID:tRNA-Ala-TGC-2-1
Anticodon:AlaTGC
tRNA_number:trna66
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 28611281        End Site(bp): 28611293+3



tsRNA Association Statistics

Total Associated Disease Number:1
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D001943DOID:1612
Disease Name:Breast Neoplasmsbreast cancer
Category:MeSHDisease Ontology
Type:Neoplasms//Skin and Connective Tissue Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:Tumors or cancer of the human BREAST.A thoracic cancer that originates in the mammary gland.
Alias:Breast Cancer//Breast Carcinoma//Breast Tumors//Cancer of Breast//Cancer of the Breast//Human Mammary Carcinoma//Malignant Neoplasm of Breast//Malignant Tumor of Breast//Mammary Cancer//Mammary Carcinoma, Human//Mammary Neoplasm, Human//Mammary Neoplasms, Human//Neoplasms, Breast//Tumors, Breastbreast tumor//malignant neoplasm of breast//malignant tumor of the breast//mammary cancer//mammary neoplasm//mammary tumor//primary breast cancer



Disease Association Statistics

Total Associated tsRNA Number:549
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:36765853
Disease Name:Breast Neoplasms
Tissue:Breast Cancer Serum Samples
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:tRF-16-K8J7K1B, a novel small ncRNA derived from the 3-end of tRNAAla-TGC, was highly expressed in tamoxifen-resistant cells compared to parental cells.
Comparision:Resistence VS Sensitive
Mechanism:Mechanistically, exosomal tRF-16K8J7K1B downregulated the expression of apoptosis-related proteins by targeting TRAIL, resulting in decreased cell apoptosis and tamoxifen resistance.