Entry Detail


General Information

Database ID:TRD01905
Confidence:Median
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-Ala-AGC-010
tsRNA Type:tRF-3
Amino acid and Anticodon:AlaAGC
Sequence:TCCCCGGCACCTCCACCA
Related Target:N/A
Predicted Target:SEC14L1//RAB43//ISY1-RAB43//FAM171A2//SMTN//RIC3//RETREG3//EGLN3//DCHS1//PLXNB1
External Links:
MINTbase ID:tRF-18-8R6546D2
tRFdb ID:tRFdb-3020a

[1] gtRNAdb_ID:tRNA-Ala-AGC-3-1
Anticodon:AlaAGC
tRNA_number:trna65
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 28574990        End Site(bp): 28575004+3

[2] gtRNAdb_ID:tRNA-Ala-AGC-2-2
Anticodon:AlaAGC
tRNA_number:trna101
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 28831462-3        End Site(bp): 28831476

[3] gtRNAdb_ID:tRNA-Ala-AGC-2-1
Anticodon:AlaAGC
tRNA_number:trna102
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 28806221-3        End Site(bp): 28806235

[4] gtRNAdb_ID:tRNA-Ala-TGC-6-1
Anticodon:AlaTGC
tRNA_number:trna113
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 28726141-3        End Site(bp): 28726155

[5] gtRNAdb_ID:tRNA-Ala-TGC-1-1
Anticodon:AlaTGC
tRNA_number:trna110
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 28757547-3        End Site(bp): 28757561



tsRNA Association Statistics

Total Associated Disease Number:3
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D009914DOID:5773
Disease Name:Oral Submucous Fibrosisoral submucous fibrosis
Category:MeSHDisease Ontology
Type:Stomatognathic Diseasesdisease of anatomical entity
Define:Irreversible FIBROSIS of the submucosal tissue of the MOUTH.A mouth disease that is characterized by juxta-epithelial inflammatory reaction and progressive fibrosis of the submucosal tissues.
Alias:N/AOral cavity Submucous Fibrosis//Oral submucosal fibrosis//Oral submucosal fibrosis, including of tongue



Disease Association Statistics

Total Associated tsRNA Number:126
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:N/A
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:34558114
Disease Name:Oral Submucous Fibrosis
Tissue:Oral Submucous Fibrosis
Dysfunction Pattern:Down-Regulation
Validated Method:High-throughput sequencing
Description:Of 126 tsRNAs in OSF were dysregulated, including 73 upregulated tsRNAs and 53 downregulated tsRNAs. The downregulated tiRNA-Val-CAC-002,tRF-Asn-GTT-005, tRF-Trp-CCA-007 and upregulated tRF-Gly-TCC-016,tRF-Pro-TGG-009 showed significant differences by qRT-PCR validation.
Comparision:Disease VS Control
Mechanism:tRNA-derived fragments are dysregulated and could be involved in the pathogenesis of oral submucous fibrosis.