Entry Detail


General Information

Database ID:TRD01875
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:3'tRF-CAT1
tsRNA Type:tRF-3
Amino acid and Anticodon:AlaAGC
Sequence:TCCCCAGTACCTCCACCA
Related Target:NOTCH2
Predicted Target:SEC14L1//RIC3//GNPTAB//RETREG3//C6orf223//SNX33//KLF14//COLGALT1//PDE6C//SEMA3G
External Links:
MINTbase ID:tRF-18-8R1546D2
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Ala-AGC-1-1
Anticodon:AlaAGC
tRNA_number:trna108
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 28763741-3        End Site(bp): 28763755



tsRNA Association Statistics

Total Associated Disease Number:55
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D002292DOID:4467
Disease Name:Carcinoma, Renal Cellclear cell renal cell carcinoma
Category:MeSHDisease Ontology
Type:Neoplasms//Urogenital Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope.
Alias:Adenocarcinoma Of Kidney//Adenocarcinoma, Renal//Adenocarcinoma, Renal Cell//Carcinoma, Hypernephroid//Chromophil Renal Cell Carcinoma//Chromophobe Renal Cell Carcinoma//Clear Cell Renal Carcinoma//Clear Cell Renal Cell Carcinoma//Collecting Duct Carcinoma//Collecting Duct Carcinoma (Kidney)//Collecting Duct Carcinoma of the Kidney//Grawitz Tumor//Hypernephroma//Nephroid Carcinoma//Papillary Renal Cell Carcinoma//Renal Carcinoma//Renal Cell Cancer//Renal Cell Carcinoma//Renal Cell Carcinoma, Papillary//Renal Collecting Duct Carcinoma//Sarcomatoid Renal Cell CarcinomaClear cell carcinoma of kidney//clear cell kidney carcinoma//Clear-cell metastatic renal cell carcinoma//Clear-cell metastatic renal cell carcinoma//conventional (Clear cell) renal cell carcinoma conventional renal cell carcinoma [EXACT] renal clear cell carcinoma [EXACT]



Disease Association Statistics

Total Associated tsRNA Number:17
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:37943661
Disease Name:Carcinoma, Renal Cell
Tissue:N/A
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:Pan-cancer tRNA-derived fragment CAT1 coordinates RBPMS to stabilize NOTCH2 mRNA to promote tumorigenesis.
Comparision:Cancer VS Normal
Mechanism:We demonstrate that a pan-cancer 30 -tRF, CAT1 (cancer associated tRF 1), is ubiquitously upregulated in tumors and associated with poor prognosis of a variety of cancers, including lung cancer. The upregulated CAT1 in cancer cells binds to RNA-binding protein with multiple splicing (RBPMS) and displaces NOTCH2 association from RBPMS, thereby inhibiting the subsequent CCR4-NOT deadenylation-complexmediated NOTCH2 mRNA decay. The CAT1-enhanced NOTCH2 expression promotes lung cancer cell proliferation and metastasis in vitro and in vivo. In addition, plasma CAT1 levels are substantially increased in patients with lung cancer compared to non-cancer control subjects. Our findings reveal an intrinsic connection between cancer-specific upregulation of CAT1 and cancer progression, show the regulation of NOTCH signaling in cancer by a 30 -tRF, and highlight its great clinical potentia.