Entry Detail


General Information

Database ID:TRD01873
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:3'tRF-CAT1
tsRNA Type:tRF-3
Amino acid and Anticodon:AlaAGC
Sequence:TCCCCAGTACCTCCACCA
Related Target:NOTCH2
Predicted Target:SEC14L1//RIC3//GNPTAB//RETREG3//C6orf223//SNX33//KLF14//COLGALT1//PDE6C//SEMA3G
External Links:
MINTbase ID:tRF-18-8R1546D2
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Ala-AGC-1-1
Anticodon:AlaAGC
tRNA_number:trna108
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 28763741-3        End Site(bp): 28763755



tsRNA Association Statistics

Total Associated Disease Number:55
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D018270DOID:3008
Disease Name:Carcinoma, Ductal, Breastinvasive ductal carcinoma
Category:MeSHDisease Ontology
Type:Neoplasms//Skin and Connective Tissue Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.A breast ductal carcinoma that is characterized by infiltration into the fibrous or fatty tissue of the breast outside of the duct where it originated.
Alias:Carcinoma, Infiltrating Duct//Carcinoma, Invasive Ductal, Breast//Carcinoma, Mammary Ductal//Invasive Ductal Carcinoma, Breast//Mammary Ductal Carcinomaductal adenocarcinoma//Infiltrating ductal carcinoma of breast//Invasive ductal carcinoma, NST



Disease Association Statistics

Total Associated tsRNA Number:26
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:37943661
Disease Name:Carcinoma, Ductal, Breast
Tissue:N/A
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:Pan-cancer tRNA-derived fragment CAT1 coordinates RBPMS to stabilize NOTCH2 mRNA to promote tumorigenesis.
Comparision:Cancer VS Normal
Mechanism:We demonstrate that a pan-cancer 30 -tRF, CAT1 (cancer associated tRF 1), is ubiquitously upregulated in tumors and associated with poor prognosis of a variety of cancers, including lung cancer. The upregulated CAT1 in cancer cells binds to RNA-binding protein with multiple splicing (RBPMS) and displaces NOTCH2 association from RBPMS, thereby inhibiting the subsequent CCR4-NOT deadenylation-complexmediated NOTCH2 mRNA decay. The CAT1-enhanced NOTCH2 expression promotes lung cancer cell proliferation and metastasis in vitro and in vivo. In addition, plasma CAT1 levels are substantially increased in patients with lung cancer compared to non-cancer control subjects. Our findings reveal an intrinsic connection between cancer-specific upregulation of CAT1 and cancer progression, show the regulation of NOTCH signaling in cancer by a 30 -tRF, and highlight its great clinical potentia.