Entry Detail


General Information

Database ID:TRD01871
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:3'tRF-CAT1
tsRNA Type:tRF-3
Amino acid and Anticodon:AlaAGC
Sequence:TCCCCAGTACCTCCACCA
Related Target:NOTCH2
Predicted Target:SEC14L1//RIC3//GNPTAB//RETREG3//C6orf223//SNX33//KLF14//COLGALT1//PDE6C//SEMA3G
External Links:
MINTbase ID:tRF-18-8R1546D2
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Ala-AGC-1-1
Anticodon:AlaAGC
tRNA_number:trna108
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 28763741-3        End Site(bp): 28763755



tsRNA Association Statistics

Total Associated Disease Number:55
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D000077192DOID:3910
Disease Name:Adenocarcinoma of Lunglung adenocarcinoma
Category:MeSHDisease Ontology
Type:Neoplasmsdisease of anatomical entity//disease of cellular proliferation
Define:A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin.
Alias:Lung Adenocarcinomaadenocarcinoma of lung//bronchogenic lung adenocarcinoma//nonsmall cell adenocarcinoma



Disease Association Statistics

Total Associated tsRNA Number:203
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:37943661
Disease Name:Adenocarcinoma of Lung
Tissue:N/A
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:Pan-cancer tRNA-derived fragment CAT1 coordinates RBPMS to stabilize NOTCH2 mRNA to promote tumorigenesis.
Comparision:Cancer VS Normal
Mechanism:We demonstrate that a pan-cancer 30 -tRF, CAT1 (cancer associated tRF 1), is ubiquitously upregulated in tumors and associated with poor prognosis of a variety of cancers, including lung cancer. The upregulated CAT1 in cancer cells binds to RNA-binding protein with multiple splicing (RBPMS) and displaces NOTCH2 association from RBPMS, thereby inhibiting the subsequent CCR4-NOT deadenylation-complexmediated NOTCH2 mRNA decay. The CAT1-enhanced NOTCH2 expression promotes lung cancer cell proliferation and metastasis in vitro and in vivo. In addition, plasma CAT1 levels are substantially increased in patients with lung cancer compared to non-cancer control subjects. Our findings reveal an intrinsic connection between cancer-specific upregulation of CAT1 and cancer progression, show the regulation of NOTCH signaling in cancer by a 30 -tRF, and highlight its great clinical potentia.