| [1] PubMed ID: | 37389118 |
| Disease Name: | Colorectal Neoplasms |
| Tissue: | Colon |
| Dysfunction Pattern: | Up-Regulation |
| Validated Method: | High-throughput sequencing |
| Description: | Differences in tRFs and tiRNAs found in SSLs and NCs were determined under the following conditions: absolute log2 (fold change) ≥ 1.5 and P < 0.05. Under these conditions, we identified 52 upregulated and 28 downregulated tRFs and tiRNAs and have shown them in a hierarchical cluster heatmap (Figure (Figure1D1D). |
| Comparision: | SSL VS Normal |
| Mechanism: | N/A |
| [2] PubMed ID: | 37864471 |
| Disease Name: | Colorectal Neoplasms |
| Tissue: | Colon |
| Dysfunction Pattern: | Up-Regulation |
| Validated Method: | RT-PCR//High-throughput sequencing |
| Description: | The expression of these tsRNAs in SW620/R and HCT116/R cells was validated by qRT‐PCR (Figure 3), which revealed that tRF‐30.43‐Gln‐CTG‐1‐M6 and tRF‐1.30‐Glu‐TTC‐3‐M2 were substantially upregulated in both radiation‐resistant cell lines, while tiRNA‐1.33‐Pro‐TGG‐3 and tRF‐1.16‐chrM.Phe‐GAA was markedly downregulated, consistent with the sequencing results. |
| Comparision: | Radiation‐Resistant VS Wild‐Type Cells |
| Mechanism: | N/A |
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