Entry Detail


General Information

Database ID:TRD01666
Confidence:Median
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:ts-60
tsRNA Type:tRF-1
Amino acid and Anticodon:CysGCA
Sequence:CTGTGCTCTGGAGTTT
Related Target:N/A
Predicted Target:RAB36//PTPN7//FAM49A//TAF6L//UNC80//ITLN1//SNX4//TMOD1//MROH2A//KLK8
External Links:
MINTbase ID:N/A
tRFdb ID:ts-60



tsRNA Association Statistics

Total Associated Disease Number:2
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D005910DOID:0060108
Disease Name:Gliomabrain glioma
Category:MeSHDisease Ontology
Type:Neoplasmsdisease of cellular proliferation//disease of anatomical entity
Define:Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)A brain cancer that has_material_basis_in glial cells.
Alias:Glial Cell Tumors//Malignant Glioma//Mixed Gliomalower grade glioma



Disease Association Statistics

Total Associated tsRNA Number:29
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:N/A
Weak Evidence:Data Mining



Reference

[1] PubMed ID:36426134
Disease Name:Glioma
Tissue:Brain
Dysfunction Pattern:Down-Regulation
Validated Method:Data Mining
Description:It displayed that the expressions of four tsRNAs (including tRFdb-3003/b, ts-55 and ts-60) were down-regulated in astrocytoma specimens compared to non-tumors (Figure 1(b), all P < 0.05).
Comparision:Cancer VS Normal
Mechanism:The tRNA-Cys-GCA derived tRFdb-3003a and tRFdb-3003b might act as key player in tumor progressions of gliomas; tRFdb-3003a/b might directly bind to VAV2 and regulate VAV2 expressions in gliomas.