Entry Detail


General Information

Database ID:TRD01615
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tsRNA-1599
tsRNA Type:i-tRF
Amino acid and Anticodon:N/A
Sequence:N/A
Related Target:HK2
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:1
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:N/ADOID:1687
Disease Name:N/Aneovascular glaucoma
Category:MeSHDisease Ontology
Type:N/Adisease of anatomical entity
Define:N/AA glaucoma characterized by narrowing of the anterior chamber angle secondary to neovascularization along the iris and iridocorneal angle such that the aqueous fluid outflow is blocked and intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Neovascular glaucoma has_symptom progressive peripheral vision loss, decreased vision, and pain, redness, and headache in acute cases. Neovascular glaucoma can be related to abnormal angiogenesis with ischemic retinal diseases, inflammation, diabetes mellitus, intraocular malignancy, and autoimmune diseases.
Alias:N/Asecondary angle-closure glaucoma with rubeosis



Disease Association Statistics

Total Associated tsRNA Number:1
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR//Western blot
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:38948065
Disease Name:neovascular glaucoma
Tissue:Vessel
Dysfunction Pattern:N/A
Validated Method:RT-PCR//Western blot//High-throughput sequencing
Description:TsRNA-1599 is shown as a pro-angiogenic factor in ocular angiogenesis
Comparision:Disease VS Control
Mechanism:His finding has great implications for the advancement of anti-angiogenic treatment. Specifically, we have identified a novel regulator of pathological angiogenesis that appears to indirectly affect VEGF signaling. Although we reveal that the effect of tsRNA-1599 is endothelial-specific, tsRNA-1599 may also play important roles in non-vascular retinal cells such as neural stem cells, ependymal cells, and photoreceptors. In addition, tsRNA-1599 plays its regulatory role in ocular angiogenesis via interacting with YBX1. As a DNA and RNA binding protein, YBX1 is potentially involved in both transcriptional and post-transcriptional gene regulation. It can participate in regulating the expression of numerous genes and bring about broad impacts beyond metabolic reprogramming. In the future, its manipulation safety should be concerned. Moreover, the role of tsRNA-1599 in neurotrophic effects are still required for further investigation.