Entry Detail


General Information

Database ID:TRD01218
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-30-3JVIJMRPFQ5D
tsRNA Type:i-tRF
Amino acid and Anticodon:LysCTT
Sequence:CCGGCTAGCTCAGTCGGTAGAGCATGAGAC
Related Target:N/A
Predicted Target:COMMD2//RPS6KA2//CFAP410//B3GNT4//EBI3//ALG14//CSRNP2//CD69//PES1//INTS6
External Links:
MINTbase ID:tRF-30-3JVIJMRPFQ5D
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Lys-CTT-3-1
Anticodon:LysCTT
tRNA_number:trna32
Chromosome:16
Strand:-
Coordinate:Start Site(bp): 3207447        End Site(bp): 3207476

[2] gtRNAdb_ID:tRNA-Lys-CTT-2-1
Anticodon:LysCTT
tRNA_number:trna119
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 145395563        End Site(bp): 145395592

[3] gtRNAdb_ID:tRNA-Lys-CTT-2-5
Anticodon:LysCTT
tRNA_number:trna7
Chromosome:16
Strand:+
Coordinate:Start Site(bp): 3225694        End Site(bp): 3225723

[4] gtRNAdb_ID:tRNA-Lys-CTT-2-3
Anticodon:LysCTT
tRNA_number:trna11
Chromosome:5
Strand:-
Coordinate:Start Site(bp): 180649020        End Site(bp): 180649049

[5] gtRNAdb_ID:tRNA-Lys-CTT-2-2
Anticodon:LysCTT
tRNA_number:trna9
Chromosome:5
Strand:+
Coordinate:Start Site(bp): 180634757        End Site(bp): 180634786

[6] gtRNAdb_ID:tRNA-Lys-CTT-2-4
Anticodon:LysCTT
tRNA_number:trna13
Chromosome:6
Strand:+
Coordinate:Start Site(bp): 26556776        End Site(bp): 26556805



tsRNA Association Statistics

Total Associated Disease Number:5
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D006332N/A
Disease Name:CardiomegalyN/A
Category:MeSHDisease Ontology
Type:Cardiovascular Diseases//Pathological Conditions, Signs and SymptomsN/A
Define:Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.N/A
Alias:Cardiac Hypertrophy//Enlarged Heart//Heart Enlargement//Heart HypertrophyN/A



Disease Association Statistics

Total Associated tsRNA Number:68
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:37370960
Disease Name:Cardiomegaly
Tissue:Plasma
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:As shown in Figure 3A, the expression levels of tRF-30-3JVIJMRPFQ5D, tRF-16-R29P4PE, tRF-21-NB8PLML3E, and tRF-21-SWRYVMMV0 were significantly downregulated (p < 0.05 or p < 0.01).
Comparision:Disease VS Control
Mechanism:Data Mining revealed that the target genes of tRF-21-NB8PLML3E were mainly enriched in the metabolic pathway and involved in the regulation of ribosomes.