Entry Detail


General Information

Database ID:TRD00997
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-21
tsRNA Type:i-tRF
Amino acid and Anticodon:GlyGCC
Sequence:TAGAATTCTCGCCTGCCACGC
Related Target:N/A
Predicted Target:FCGR2A//ZNF668//CTBS//SOX11//IFI30//AC007192.1//LTB4R//PRSS55//RBCK1//C6orf223
External Links:
MINTbase ID:tRF-21-VBY9PYKHD
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Gly-GCC-3-1
Anticodon:GlyGCC
tRNA_number:trna25
Chromosome:16
Strand:-
Coordinate:Start Site(bp): 70812146        End Site(bp): 70812166

[2] gtRNAdb_ID:tRNA-Gly-GCC-2-1
Anticodon:GlyGCC
tRNA_number:trna68
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161493669        End Site(bp): 161493689

[3] gtRNAdb_ID:tRNA-Gly-GCC-2-5
Anticodon:GlyGCC
tRNA_number:trna19
Chromosome:16
Strand:+
Coordinate:Start Site(bp): 70823428        End Site(bp): 70823448

[4] gtRNAdb_ID:tRNA-Gly-GCC-2-4
Anticodon:GlyGCC
tRNA_number:trna24
Chromosome:16
Strand:-
Coordinate:Start Site(bp): 70812974        End Site(bp): 70812994

[5] gtRNAdb_ID:tRNA-Gly-GCC-2-6
Anticodon:GlyGCC
tRNA_number:trna5
Chromosome:17
Strand:+
Coordinate:Start Site(bp): 8029082        End Site(bp): 8029102

[6] gtRNAdb_ID:tRNA-Gly-GCC-2-2
Anticodon:GlyGCC
tRNA_number:trna19
Chromosome:2
Strand:-
Coordinate:Start Site(bp): 157257691        End Site(bp): 157257711

[7] gtRNAdb_ID:tRNA-Gly-GCC-2-3
Anticodon:GlyGCC
tRNA_number:trna128
Chromosome:6
Strand:-
Coordinate:Start Site(bp): 27870718        End Site(bp): 27870738

[8] gtRNAdb_ID:tRNA-Gly-GCC-1-1
Anticodon:GlyGCC
tRNA_number:trna35
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161413112        End Site(bp): 161413132

[9] gtRNAdb_ID:tRNA-Gly-GCC-1-2
Anticodon:GlyGCC
tRNA_number:trna37
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161420485        End Site(bp): 161420505

[10] gtRNAdb_ID:tRNA-Gly-GCC-1-3
Anticodon:GlyGCC
tRNA_number:trna39
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161427916        End Site(bp): 161427936

[11] gtRNAdb_ID:tRNA-Gly-GCC-1-4
Anticodon:GlyGCC
tRNA_number:trna41
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161435276        End Site(bp): 161435296

[12] gtRNAdb_ID:tRNA-Gly-GCC-1-5
Anticodon:GlyGCC
tRNA_number:trna2
Chromosome:21
Strand:-
Coordinate:Start Site(bp): 18827139        End Site(bp): 18827159



tsRNA Association Statistics

Total Associated Disease Number:3
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D021441DOID:3498
Disease Name:Carcinoma, Pancreatic Ductalpancreatic ductal adenocarcinoma
Category:MeSHDisease Ontology
Type:Neoplasms//Digestive System Diseases//Endocrine System Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.A pancreatic adenocarcinoma that derives_from pancreatic duct cells.
Alias:Carcinoma, Ductal, Pancreatic//Duct-Cell Carcinoma of the Pancreas//Duct-Cell Carcinoma, Pancreas//Ductal Carcinoma of the Pancreas//Pancreatic Duct Cell Carcinoma//Pancreatic Ductal Carcinomaductal adenocarcinoma of the pancreas



Disease Association Statistics

Total Associated tsRNA Number:114
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:Northern blot
Weak Evidence:Data Mining



Reference

[1] PubMed ID:34779408
Disease Name:Carcinoma, Pancreatic Ductal
Tissue:Pancreatic Ductal Adenocarcinoma
Dysfunction Pattern:Down-Regulation
Validated Method:Northern blot//Data Mining
Description:The tRF-21 levels were significantly lower in PDACs than in normal tissues, and patients with low tRF-21 levels had a poor prognosis.
Comparision:Cancer VS Normal
Mechanism:Reduced tRF-21 promoted AKT2/1-mediated heterogeneous nuclear ribonucleoprotein L (hnRNP L) phosphorylation, enhancing hnRNP L to interact with dead-box helicase 17 (DDX17) to form an alternative splicing complex.