Entry Detail


General Information

Database ID:TRD00977
Confidence:Median
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:i-tRF-GlyCCC
tsRNA Type:i-tRF
Amino acid and Anticodon:GlyGCC
Sequence:N/A
Related Target:N/A
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:1
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D007938DOID:1240
Disease Name:Leukemialeukemia
Category:MeSHDisease Ontology
Type:Neoplasmsdisease of anatomical entity//disease of cellular proliferation
Define:A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells.
Alias:Leucocythaemia//LeucocythemiaN/A



Disease Association Statistics

Total Associated tsRNA Number:14
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:N/A



Reference

[1] PubMed ID:31669784
Disease Name:Leukemia
Tissue:Peripheral Blood Mononuclear Cells
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR
Description:N/A
Comparision:CLL VS Normal
Mechanism:The biostatistical analysis revealed that i-tRF-GlyCCC levels are significantly lower in PBMCs of CLL patients, compared to PBMCs of non-leukemic controls, and that i-tRF-GlyCCC could be considered as a screening biomarker.