Entry Detail


General Information

Database ID:TRD00793
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:mt-i-tRF-GluUUC
tsRNA Type:i-tRF
Amino acid and Anticodon:GluTTC
Sequence:N/A
Related Target:N/A
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:7
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D028361N/A
Disease Name:Mitochondrial DiseasesN/A
Category:MeSHDisease Ontology
Type:Nutritional and Metabolic DiseasesN/A
Define:Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.N/A
Alias:Electron Transport Chain Deficiencies, Mitochondrial//Mitochondrial Disorders//Mitochondrial Electron Transport Chain Deficiencies//Mitochondrial Respiratory Chain Deficiencies//Oxidative Phosphorylation Deficiencies//Respiratory Chain Deficiencies, MitochondrialN/A



Disease Association Statistics

Total Associated tsRNA Number:69
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:31195049
Disease Name:Mitochondrial Diseases
Tissue:Melas Cybrid Cells
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:Mt tRFs may be biologically relevant, as one of them (mt i-tRF GluUUC), likely produced by the action of the nuclease Dicer and whose levels are Ago2 dependent, down-regulates the expression of mitochondrial pyruvate carrier 1 (MPC1), promoting the build-up of extracellular lactate.
Comparision:Mutation VS Wild
Mechanism:N/A